P-glycoprotein: New insights into structure, physiological function, regulation and alterations in disease
The multidrug resistance phenomenon presents a major threat to the pharmaceutical
industry. This resistance is a common occurrence in several diseases and is mediated by …
industry. This resistance is a common occurrence in several diseases and is mediated by …
ATP-binding cassette efflux transporters and MDR in cancer
MS Pote, RN Gacche - Drug Discovery Today, 2023 - Elsevier
Highlights•The most common reason for the failure of the cancer treatment is the evolving
drug resistance.•The ABC transporters mainly P-gp, BCRP and MRP1 are responsible for …
drug resistance.•The ABC transporters mainly P-gp, BCRP and MRP1 are responsible for …
Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation
Y Kim, J Chen - Science, 2018 - science.org
The multidrug transporter permeability (P)–glycoprotein is an adenosine triphosphate (ATP)–
binding cassette exporter responsible for clinical resistance to chemotherapy. P-glycoprotein …
binding cassette exporter responsible for clinical resistance to chemotherapy. P-glycoprotein …
Structure, gating, and regulation of the CFTR anion channel
The cystic fibrosis transmembrane conductance regulator (CFTR) belongs to the ATP
binding cassette (ABC) transporter superfamily but functions as an anion channel crucial for …
binding cassette (ABC) transporter superfamily but functions as an anion channel crucial for …
Nanotherapeutics approaches to overcome P-glycoprotein-mediated multi-drug resistance in cancer
Multidrug resistance (MDR) in cancer chemotherapy is a growing concern for medical
practitioners. P-glycoprotein (P-gp) overexpression is one of the major reasons for multidrug …
practitioners. P-glycoprotein (P-gp) overexpression is one of the major reasons for multidrug …
Passive membrane transport of lignin-related compounds
Lignin is an abundant aromatic polymer found in plant secondary cell walls. In recent years,
lignin has attracted renewed interest as a feedstock for bio-based chemicals via catalytic …
lignin has attracted renewed interest as a feedstock for bio-based chemicals via catalytic …
ABC transporter superfamily. An updated overview, relevance in cancer multidrug resistance and perspectives with personalized medicine
PDM Juan-Carlos, PP Perla-Lidia… - Molecular biology …, 2021 - Springer
The ATP binding-cassette superfamily corresponds the mostly transmembrane transporters
family found in humans. These proteins actively transport endogenous and exogenous …
family found in humans. These proteins actively transport endogenous and exogenous …
Characterization of the kinetic cycle of an ABC transporter by single-molecule and cryo-EM analyses
ATP-binding cassette (ABC) transporters are molecular pumps ubiquitous across all
kingdoms of life. While their structures have been widely reported, the kinetics governing …
kingdoms of life. While their structures have been widely reported, the kinetics governing …
[HTML][HTML] Comparison of mechanistic transport cycle models of ABC exporters
D Szöllősi, D Rose-Sperling, UA Hellmich… - Biochimica et Biophysica …, 2018 - Elsevier
ABC (ATP binding cassette) transporters, ubiquitous in all kingdoms of life, carry out
essential substrate transport reactions across cell membranes. Their transmembrane …
essential substrate transport reactions across cell membranes. Their transmembrane …
ABCB1/MDR1/P‐gp employs an ATP‐dependent twist‐and‐squeeze mechanism to export hydrophobic drugs
A Kodan, R Futamata, Y Kimura, N Kioka… - FEBS …, 2021 - Wiley Online Library
ABCB1, also called MDR1 or P‐glycoprotein, exports various hydrophobic compounds and
plays an essential role as a protective physiological barrier in several organs, including the …
plays an essential role as a protective physiological barrier in several organs, including the …