Deep learning describes a class of machine learning algorithms that are capable of
combining raw inputs into layers of intermediate features. These algorithms have recently …

Oxidative stress and chronic inflammation are known to be associated with the development
of metabolic diseases, including diabetes. Oxidative stress, an imbalance between oxidative …

Apoptosis plays a vital role in cell homeostasis during development and disease. Bcl-x, a
member of the Bcl-2 family of proteins, is a mitochondrial transmembrane protein that …

Abstract Background Type 1 diabetes (T1D) results from immune-mediated destruction of
insulin-producing beta cells. Prevention efforts have focused on immune modulation and …

Advancements in genomic research such as high-throughput sequencing techniques have
driven modern genomic studies into" big data" disciplines. This data explosion is constantly …

Pre-mRNA splicing is a key controller of human gene expression. Disturbances in splicing
due to mutation lead to dysregulated protein expression and contribute to a substantial …

Prior to the onset of type 1 diabetes, there is progressive loss of immune self-tolerance,
evidenced by the accumulation of islet autoantibodies and emergence of autoreactive T …

Abnormalities in alternative splicing (AS) are emerging as recurrent features in autoimmune
diseases (AIDs). In particular, a growing body of evidence suggests the existence of a …

The data explosion driven by advancements in genomic research, such as high-throughput
sequencing techniques, is constantly challenging conventional methods used in genomics …

Long non-coding RNAs (lncRNAs) are post-transcriptional and epigenetic regulators, whose
implication in neurodegenerative and autoimmune diseases remains poorly understood. We …