Interval between two-stage exchanges: what is optimal and how do you know?

R Sousa, A Carvalho, D Soares, MA Abreu - Arthroplasty, 2023 - Springer
Background Two-stage exchange arthroplasty remains the most popular option for the
treatment of chronic periprosthetic joint infection (PJI). Determining infection eradication and …

Reliable Diagnostic Tests and Thresholds for Preoperative Diagnosis of Non‐Inflammatory Arthritis Periprosthetic Joint Infection: A Meta‐analysis and Systematic …

H Tang, J Xu, W Yuan, Y Wang, B Yue… - Orthopaedic …, 2022 - Wiley Online Library
Objective The current diagnostic criteria for periprosthetic joint infection (PJI) are diverse and
controversial, leading to delayed diagnosis. This study aimed to evaluate and unify their …

The value of calprotectin in synovial fluid for the diagnosis of chronic prosthetic joint infection

Z Zhang, Y Cai, G Bai, C Zhang, W Li… - Bone & joint …, 2020 - boneandjoint.org.uk
Aims This study aimed to evaluate calprotectin in synovial fluid for diagnosing chronic
prosthetic joint infection (PJI). Methods A total of 63 patients who were suspected of PJI were …

Does the alpha defensin ELISA test perform better than the alpha defensin lateral flow test for PJI diagnosis? A systematic review and meta-analysis of prospective …

JWP Kuiper, SJ Verberne, SJ Vos… - … and Related Research …, 2020 - journals.lww.com
Background Periprosthetic joint infection (PJI) following total joint arthroplasty is a serious
complication that causes severe morbidity and adds a major financial burden to the …

Utility of diagnostic tests before reimplantation in patients undergoing 2-stage revision total joint arthroplasty: a systematic review and meta-analysis

IA Khan, BO Boyd, AF Chen, N Cortés-Penfield… - JBJS …, 2023 - journals.lww.com
Methods: The Cochrane Library, PubMed (MEDLINE), and EMBASE were searched for
randomized controlled trials and comparative observational studies published before …

Alpha-defensin offers limited utility in work-up prior to reimplantation in chronic periprosthetic joint infection in total joint arthroplasty patients

JM Owens, DA Dennis, PM Abila, RM Johnson… - The Journal of …, 2022 - Elsevier
Background Alpha-defensin (AD) is a synovial biomarker included in the 2018 consensus
criteria for diagnosing periprosthetic joint infection (PJI). Its value in assessing eradication of …

Does serum interleukin-6 guide the diagnosis of persistent infection in two-stage hip revision for periprosthetic joint infection?

PF Qu, C Xu, J Fu, R Li, W Chai, JY Chen - Journal of Orthopaedic Surgery …, 2019 - Springer
Purpose The diagnosis of persistent infection at reimplantation of two-stage revision
arthroplasty for periprosthetic joint infection (PJI) remains challenging. Several studies have …

What is the clinical utility of synovial alpha defensin testing of antibiotic spacers before reimplantation?

CN Carender, DE DeMik, JE Otero, NO Noiseux… - The Journal of …, 2021 - Elsevier
Background The purpose of this study was to evaluate the diagnostic performance of
standalone alpha defensin (AD) testing of antibiotic spacers during two stage exchange and …

Leukocyte scintigraphy has high specificity but low sensitivity in diagnosing persistent periprosthetic joint infection before reimplantation in two-stage revision

ML Presti, C Vasco, MP Neri, L Solito… - Archives of Orthopaedic …, 2025 - Springer
Results The final cohort included 67 cases in 61 patients (M: F= 32: 35; mean age 74 years).
There were 43 true negatives, 8 true positives, 12 false negatives, and 4 false positives. The …

Upcoming evidence in clinical practice of two-stage revision arthroplasty for prosthetic joint infection

T Ascione, G Balato, P Pagliano - Journal of Orthopaedics and …, 2024 - Springer
Total joint arthroplasty is the recommended treatment for patients with end-stage
osteoarthritis, as it reduces disability and pain and restores joint function. However …