EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: definition, characterization, and clinical implication

A Goette, JM Kalman, L Aguinaga, J Akar… - Heart …, 2016 - pmc.ncbi.nlm.nih.gov
The atria provide an important contribution to cardiac function. 1, 2 Besides their impact on
ventricular filling, they serve as a volume reservoir, host pacemaker cells and important parts …

Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression

J Heijman, N Voigt, S Nattel, D Dobrev - Circulation research, 2014 - Am Heart Assoc
Atrial fibrillation (AF) is the most common clinically relevant arrhythmia and is associated
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …

EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: definition, characterization, and clinical implication

A Goette, JM Kalman, L Aguinaga, J Akar… - Ep …, 2016 - academic.oup.com
The atria provide an important contribution to cardiac function. 1, 2 Besides their impact on
ventricular filling, they serve as a volume reservoir, host pacemaker cells and important parts …

Generating ring-shaped engineered heart tissues from ventricular and atrial human pluripotent stem cell-derived cardiomyocytes

I Goldfracht, S Protze, A Shiti, N Setter, A Gruber… - Nature …, 2020 - nature.com
The functions of the heart are achieved through coordination of different cardiac cell
subtypes (eg, ventricular, atrial, conduction-tissue cardiomyocytes). Human pluripotent stem …

Pathophysiological mechanisms of atrial fibrillation: a translational appraisal

U Schotten, S Verheule, P Kirchhof… - Physiological …, 2011 - journals.physiology.org
Atrial fibrillation (AF) is an arrhythmia that can occur as the result of numerous different
pathophysiological processes in the atria. Some aspects of the morphological and …

Enhanced Sarcoplasmic Reticulum Ca2+ Leak and Increased Na+-Ca2+ Exchanger Function Underlie Delayed Afterdepolarizations in Patients With Chronic Atrial …

N Voigt, N Li, Q Wang, W Wang, AW Trafford… - Circulation, 2012 - Am Heart Assoc
Background—Delayed afterdepolarizations (DADs) carried by Na+-Ca2+-exchange current
(INCX) in response to sarcoplasmic reticulum (SR) Ca2+ leak can promote atrial fibrillation …

Recent advances in the molecular pathophysiology of atrial fibrillation

R Wakili, N Voigt, S Kääb, D Dobrev… - The Journal of clinical …, 2011 - Am Soc Clin Investig
Atrial fibrillation (AF) is an extremely common cardiac rhythm disorder that causes
substantial morbidity and contributes to mortality. The mechanisms underlying AF are …

Atrial remodeling and atrial fibrillation: mechanisms and implications

S Nattel, B Burstein, D Dobrev - Circulation: Arrhythmia and …, 2008 - Am Heart Assoc
Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. It can occur at any
age but is very rare in children and becomes extremely common in the elderly, with a …

Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation

S Nattel, A Maguy, S Le Bouter… - Physiological …, 2007 - journals.physiology.org
Rhythmic and effective cardiac contraction depends on appropriately timed generation and
spread of cardiac electrical activity. The basic cellular unit of such activity is the action …

Human Atrial Action Potential and Ca2+ Model: Sinus Rhythm and Chronic Atrial Fibrillation

E Grandi, SV Pandit, N Voigt, AJ Workman… - Circulation …, 2011 - Am Heart Assoc
Rationale: Understanding atrial fibrillation (AF) requires integrated understanding of ionic
currents and Ca2+ transport in remodeled human atrium, but appropriate models are limited …