T-2 toxin, a trichothecene mycotoxin: review of toxicity, metabolism, and analytical methods

Y Li, Z Wang, RC Beier, J Shen, DD Smet… - Journal of agricultural …, 2011 - ACS Publications
This review focuses on the toxicity and metabolism of T-2 toxin and analytical methods used
for the determination of T-2 toxin. Among the naturally occurring trichothecenes in food and …

An update on T2-toxins: metabolism, immunotoxicity mechanism and human assessment exposure of intestinal microbiota

J Zhang, X Liu, Y Su, T Li - Heliyon, 2022 - cell.com
Mycotoxins are naturally produced secondary metabolites or low molecular organic
compounds produced by fungus with high diversification, which cause mycotoxicosis (food …

Comparative cytotoxicity of deoxynivalenol, nivalenol, their acetylated derivatives and de-epoxy metabolites

GS Eriksen, H Pettersson, T Lundh - Food and Chemical Toxicology, 2004 - Elsevier
The cytotoxicity of the de-epoxy metabolites of trichothecenes nivalenol (NIV) and
deoxynivalenol (DON) was determined and compared with the cytotoxicity of the respective …

Scientific Opinion on the risks for animal and public health related to the presence of T‐2 and HT‐2 toxin in food and feed

EFSA Panel on Contaminants in the Food Chain … - EFSA …, 2011 - Wiley Online Library
Abstract T‐2 toxin and HT‐2 toxin are mycotoxins produced by various Fusarium species.
The European Commission asked EFSA for a scientific opinion on the risk to human and …

Different apoptotic pathways induced by zearalenone, T-2 toxin and ochratoxin A in human hepatoma cells

C Bouaziz, E El Golli, S Abid-Essefi, C Brenner… - Toxicology, 2008 - Elsevier
Mycotoxins, secondary metabolites produced by moulds, have been shown to cause diverse
toxic effects in animals and are also suspected of disease causation in humans. The present …

Metabolism and cytotoxic effects of T-2 toxin and its metabolites on human cells in primary culture

M Königs, D Mulac, G Schwerdt, M Gekle, HU Humpf - Toxicology, 2009 - Elsevier
T-2 toxin belongs to the large group of trichothecene mycotoxins synthesized by various
Fusarium molds which can infect raw agriculture materials. Among the trichothecenes, T-2 …

[HTML][HTML] Evaluating the combined and individual cytotoxic effect of beauvericin, enniatin B and ochratoxin a on breast cancer cells, leukemia cells, and fresh peripheral …

A Juan-García, AM Ilie, C Juan, L Martínez - Toxicology in Vitro, 2024 - Elsevier
Abstract Beauvericin (BEA), Enniatin B (ENN B), and Ochratoxin A (OTA) are mycotoxins
produced by fungi species. Their main effect on several organs and systems is associated …

T-2 toxin-induced apoptosis involving Fas, p53, Bcl-xL, Bcl-2, Bax and caspase-3 signaling pathways in human chondrocytes

J Chen, J Cao, Y Chu, Z Wang, Z Yang… - Journal of Zhejiang …, 2008 - Springer
Objective To investigate the effects of T-2 toxin on expressions of Fas, p53, Bcl-xL, Bcl-2,
Bax and caspase-3 on human chondrocytes. Methods Human chondrocytes were treated …

Induction of competing apoptotic and survival signaling pathways in the macrophage by the ribotoxic trichothecene deoxynivalenol

HR Zhou, Z Islam, JJ Pestka - Toxicological Sciences, 2005 - academic.oup.com
Deoxynivalenol (DON) and other ribotoxic trichothecenes cause immune stimulation and
suppression in leukocytes by upregulating gene expression and apoptosis, respectively …

T-2 toxin and HT-2 toxin in grain and grain-based commodities in Europe: Occurrence, factors affecting occurrence, co-occurrence and toxicological effects

H Van der Fels-Klerx… - World Mycotoxin …, 2010 - wageningenacademic.com
This paper presents an overview of the occurrence of T-2 toxin and HT-2 toxin in cereals in
Europe and derived food products, factors influencing the occurrence, co-occurrence with …