Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets

Y Zhao, W Xiong, C Li, R Zhao, H Lu, S Song… - … and Targeted Therapy, 2023 - nature.com
Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects
the survival of aerobic species and plays a prominent role in cardiovascular diseases. From …

The signaling pathway of hypoxia inducible factor in regulating gut homeostasis

W Liu, X Fan, B Jian, D Wen, H Wang, Z Liu… - Frontiers in …, 2023 - frontiersin.org
Hypoxia represent a condition in which an adequate amount of oxygen supply is missing in
the body, and it could be caused by a variety of diseases, including gastrointestinal …

Low-intensity pulsed ultrasound of different intensities differently affects myocardial ischemia/reperfusion injury by modulating cardiac oxidative stress and …

Q Cao, L Liu, Y Hu, S Cao, T Tan, X Huang… - Frontiers in …, 2023 - frontiersin.org
Introduction The prevalence of ischemic heart disease has reached pandemic levels
worldwide. Early revascularization is currently the most effective therapy for ischemic heart …

Peroxynitrite-Free Nitric Oxide-Embedded Nanoparticles Maintain Nitric Oxide Homeostasis for Effective Revascularization of Myocardial Infarcts

J Zhang, S Wang, Q Sun, J Zhang, X Shi, M Yao… - ACS …, 2024 - ACS Publications
Revascularization is crucial for treating myocardial infarction (MI). Nitric oxide (NO), at an
appropriate concentration, is recognized as an ideal and potent pro-angiogenic factor …

Effects of obstructive sleep apnea on myocardial injury and dysfunction: a review focused on the molecular mechanisms of intermittent hypoxia

W Liu, Q Zhu, X Li, Y Wang, C Zhao, C Ma - Sleep and Breathing, 2024 - Springer
Obstructive sleep apnea (OSA) is characterized by intermittent hypoxia (IH) and is strongly
associated with adverse cardiovascular outcomes. Myocardial injury and dysfunction have …

[PDF][PDF] HSPD1 gene polymorphism is associated with an increased risk of ischemic stroke in smokers

TA Stetskaya, KA Kobzeva, SM Zaytsev, IV Shilenok… - 2024 - dspace.bsuedu.ru
HSPD1 gene polymorphism is associated with an increased risk of ischemic stroke in smokers
Page 1 Оригинальная статья Original article Научные результаты биомедицинских …

GTF2H4 regulates partial EndMT via NF-κB activation through NCOA3 phosphorylation in ischemic diseases

Z Fang, G Zhao, S Zhao, X Yu, R Feng, Y Zhang, H Li… - The Innovation, 2024 - cell.com
Partial endothelial-to-mesenchymal transition (EndMT) is an intermediate phenotype
observed in endothelial cells (ECs) undergoing a transition toward a mesenchymal state to …

[HTML][HTML] Hypoxia and panvascular diseases: exploring the role of hypoxia-inducible factors in vascular smooth muscle cells under panvascular pathologies

Y Hu, Y Zhao, P Li, H Lu, H Li, J Ge - Science Bulletin, 2023 - Elsevier
As an emerging discipline, panvascular diseases are a set of vascular diseases with
atherosclerosis as the common pathogenic hallmark, which mostly affect vital organs like the …

SIRT6 deficiency in endothelial cells exacerbates oxidative stress by enhancing HIF1α accumulation and H3K9 acetylation at the Ero1α promoter

Z Guo, X Yu, S Zhao, X Zhong, D Huang… - Clinical and …, 2023 - Wiley Online Library
Background SIRT6, an important NAD+‐dependent protein, protects endothelial cells from
inflammatory and oxidative stress injuries. However, the role of SIRT6 in cardiac …

HIF-1α-induced mitophagy regulates the regenerative outcomes of stem cells in fat transplantation

K Zhang, D Jin, X Zhao, B Lu, W Guo… - Cell …, 2023 - journals.sagepub.com
Hypoxia is a crucial factor with type diversity that plays an important role in stem cell
transplantation. However, the effects of hypoxia on adipose-derived stem cells (ADSCs) are …