The world has developed an elaborate global health system as a bulwark against known
and unknown infectious disease threats. The system consists of various formal and informal …

Background Accurate estimates of the burden of antimicrobial resistance (AMR) are needed
to establish the magnitude of this global threat in terms of both health and cost, and to …

The “WHO consolidated guidelines on tuberculosis. Module 3: Diagnosis-Rapid diagnostics
for tuberculosis detection, third edition” is the latest document replacing the one issued in …

Global tuberculosis incidence has declined marginally over the past decade, and
tuberculosis remains out of control in several parts of the world including Africa and Asia …

It is essential to acknowledge the efforts made thus far to manage or eliminate various
disease burden faced by humankind. However, the rising global trends of the so-called …

Mycobacterium tuberculosis drug resistance (DR) challenges effective tuberculosis disease
control. Current molecular tests examine limited numbers of mutations, and although whole …

Extensively drug-resistant tuberculosis is a burgeoning global health crisis mainly affecting
economically active young adults, and has high mortality irrespective of HIV status. In some …

Background Long-term treatment-related outcomes in patients with extensively drug-
resistant (XDR) tuberculosis are unknown. We followed up a cohort of patients to address …

Background Novel tuberculosis (TB) drugs and the need to treat drug-resistant tuberculosis
(DR-TB) are likely to bring about substantial transformations in TB treatment in coming …

Tuberculosis (TB) is a large global health problem, in part because of the long period of
coevolution of the pathogen, Mycobacterium tuberculosis, and its human host. A major factor …