Polyamine Adducts with AP Sites: Interaction with DNA Polymerases and AP Endonucleases
AV Yudkina, MM Amanova… - Chemical Research in …, 2025 - ACS Publications
Biological polyamines, such as spermine, spermidine, and putrescine, are abundant
intracellular compounds mostly bound to nucleic acids. Due to their nucleophilic nature …
intracellular compounds mostly bound to nucleic acids. Due to their nucleophilic nature …
Light-Driven Installation of Aminooxyhomolysine on Histones and Its Application for Synthesizing Stable and Site-Specific 3′-DNA–Histone Cross-Links
Histones react with various aldehyde-containing DNA modifications to form reversible but
long-lived DNA–histone cross-links. The investigation of their biochemical effects and repair …
long-lived DNA–histone cross-links. The investigation of their biochemical effects and repair …
Dual-responsive probe and DNA interstrand crosslink precursor target the unique redox status of cancer cells
D Yu, L Wang, J Li, X Zeng, Y Jia, J Tian… - Chemical …, 2023 - pubs.rsc.org
Elevated GSH and H2O2 in cancer cells is sometimes doubted due to their contrary
reactivities. Here, we construct a dual-responsive fluorescent probe to confirm the …
reactivities. Here, we construct a dual-responsive fluorescent probe to confirm the …
Mass Spectrometry Evidence for Forming Schiff Base 3′-DNA-Histone Cross-Links from Abasic Sites in Vitro and in Human Cells
Histones catalyze DNA strand incision at apurinic/apyrimidinic (AP) sites accompanied by
the formation of reversible but long-lived DNA–protein cross-links at 3′-termini (3′-histone …
the formation of reversible but long-lived DNA–protein cross-links at 3′-termini (3′-histone …
Human 8‐Oxoguanine Glycosylase OGG1 Cleaves Abasic Sites and Covalently Conjugates to 3′‐DNA Termini via Cysteine and Histidine Addition
Oxoguanine glycosylase 1 (OGG1) repairs the major oxidative DNA damage, 8‐oxo‐2′‐
deoxyguanosine. It has been reported that OGG1 incises the most frequently formed DNA …
deoxyguanosine. It has been reported that OGG1 incises the most frequently formed DNA …