Cutaneous lupus erythematosus (CLE) is an autoimmune disease that can present as an
isolated skin disease or as a manifestation within the spectrum of systemic lupus …

The liver is an important immunological organ that controls systemic tolerance. The liver
harbors professional and unconventional antigen-presenting cells that are crucial for …

Objectives To estimate associations between fine particulate matter (PM2. 5) and ozone and
the onset of systemic autoimmune rheumatic diseases (SARDs). Methods An open cohort of …

Abstract Background Systemic sclerosis (SSc) is a clinically complex and challenging
disease, that leads to skin fibrosis. Its most frequent complication is interstitial lung disease …

Rituximab is used to eliminate B cells as a chimeric monoclonal antibody directed against
CD20, a B-cell antigen expressed on B cells. To explore the impact of rituximab …

Chimeric antigen receptor (CAR) based therapies have been adopted as an option for
treating autoimmune diseases from the field of blood malignancies by targeting immune …

The antiphospholipid syndrome (APS) is characterized by the development of venous and/or
arterial thrombosis and pregnancy morbidity in patients with persistent antiphospholipid …

The management of connective tissue diseases is dramatically evolving with the advent of
biologics and novel oral systemic therapeutics. Despite involvement in the care of these …

According to the revised Witebsky postulates, diseases are of an autoimmune nature if,(i) the
clinical phenotype can be reproduced through the transfer of autoantibodies and/or …

Rheumatoid arthritis (RA) is a systemic inflammatory disease treated with conventional and
biologic disease-modifying drugs. Methotrexate is the anchor drug for the treatment of RA …