During development, mechanical forces cause changes in size, shape, number, position,
and gene expression of cells. They are therefore integral to any morphogenetic processes …

Embryonic cells grow in environments that provide a plethora of physical cues, including
mechanical forces that shape the development of the entire embryo. Despite their …

Cell-cell junctions respond to mechanical forces by changing their organization and
function. To gain insight into the mechanochemical basis underlying junction …

From the earliest stages of embryonic development, cells of epithelial and mesenchymal
origin contribute to the structure and function of developing organs. However, these …

The Wnt signaling pathway is an ancient and evolutionarily conserved pathway that
regulates crucial aspects of cell fate determination, cell migration, cell polarity, neural …

A long-standing goal of biology is to map the behavior of all cells during vertebrate
embryogenesis. We developed digital scanned laser light sheet fluorescence microscopy …

Epithelial–mesenchymal transition (EMT) is a process when epithelial cells gradually
transform into mesenchymal-like cells losing their epithelial functionality and characteristics …

This review addresses the cellular and molecular mechanisms of cadherin-based tissue
morphogenesis. Tissue physiology is profoundly influenced by the distinctive organizations …

Elongation of the body axis is accompanied by the assembly of a polarized cytoarchitecture
that provides the basis for directional cell behavior. We find that planar polarity in the …

For all animals, cell migration is an essential and highly regulated process. Cells migrate to
shape tissues, to vascularize tissues, in wound healing, and as part of the immune …