Humans have been using natural products for medicinal use for ages. Natural products of
therapeutic importance are compounds derived from plants, animals, or any microorganism …

Spice and medicinal plants gained an important role in agronomy production, pharmacy and
exportation because of their increased use as a raw material for the pharmaceutical industry …

Background and objectives: Zingerone is an ingredient of ginger (Zingiber officinale) with
different pharmacological activities. Several studies have investigated the effect of zingerone …

Intestinal ischemia reperfusion (I/R) injury caused by severe trauma, intestinal obstruction,
and operation is one of the tough challenges in clinic. 6-Gingerol (6G), a main active …

Acute kidney injury (AKI) is a progressive renal complication which significantly affects the
patient's life with huge economic burden. Untreated acute kidney injury eventually …

Neuroinflammation is a central factor in neuropathic pain (NP). Ginger is a promising
bioactive compound in NP management due to its anti-inflammatory property. Emerging …

Ethnopharmacological relevance Necrotizing enterocolitis (NEC) is the most important
gastrointestinal emergency affecting especially preterm infants and causes severe …

Background The dried rhizome of ginger has been widely used for more than 2500 years in
folk medicine for the treatment of various diseases that involve inflammation or are caused …

Zingerone (ZGR), a phenolic alkanone isolated from ginger, has been reported to possess
pharmacological activities such as anti-inflammatory and anti-apoptotic effects. This study …

High mobility group box 1 (HMGB1) is considered a late mediator of sepsis and the
inhibition of HMGB1-mediated severe inflammatory responses and restoration of endothelial …