Significance of bystander T cell activation in microbial infection
During microbial infection, pre-existing memory CD8+ T cells that are not specific for the
infecting pathogens can be activated by cytokines without cognate antigens, termed …
infecting pathogens can be activated by cytokines without cognate antigens, termed …
Type A viral hepatitis: A summary and update on the molecular virology, epidemiology, pathogenesis and prevention
SM Lemon, JJ Ott, P Van Damme, D Shouval - Journal of Hepatology, 2018 - Elsevier
Although epidemic jaundice was well known to physicians of antiquity, it is only in recent
years that medical science has begun to unravel the origins of hepatitis A virus (HAV) and …
years that medical science has begun to unravel the origins of hepatitis A virus (HAV) and …
The activation of bystander CD8+ T cells and their roles in viral infection
During viral infections, significant numbers of T cells are activated in a T cell receptor-
independent and cytokine-dependent manner, a phenomenon referred to as “bystander …
independent and cytokine-dependent manner, a phenomenon referred to as “bystander …
Immune responses and immunopathology in acute and chronic viral hepatitis
Hepatitis A virus (HAV), hepatitis B virus (HBV) and hepatitis C virus (HCV) are responsible
for most cases of viral hepatitis. Infection by each type of virus results in a different typical …
for most cases of viral hepatitis. Infection by each type of virus results in a different typical …
Hepatitis A virus infection
Hepatitis A is a vaccine-preventable infection caused by the hepatitis A virus (HAV). Over
150 million new infections of hepatitis A occur annually. HAV causes an acute inflammatory …
150 million new infections of hepatitis A occur annually. HAV causes an acute inflammatory …
Innate-like cytotoxic function of bystander-activated CD8+ T cells is associated with liver injury in acute hepatitis A
Acute hepatitis A (AHA) involves severe CD8+ T cell-mediated liver injury. Here we showed
during AHA, CD8+ T cells specific to unrelated viruses became activated. Hepatitis A virus …
during AHA, CD8+ T cells specific to unrelated viruses became activated. Hepatitis A virus …
Immune responses to HCV and other hepatitis viruses
SH Park, B Rehermann - Immunity, 2014 - cell.com
Five human hepatitis viruses cause most of the acute and chronic liver disease worldwide.
Over the past 25 years, hepatitis C virus (HCV) in particular has received much interest …
Over the past 25 years, hepatitis C virus (HCV) in particular has received much interest …
Cytomegalovirus infection leads to development of high frequencies of cytotoxic virus-specific CD4+ T cells targeted to vascular endothelium
Cytomegalovirus (CMV) infection elicits a very strong and sustained intravascular T cell
immune response which may contribute towards development of accelerated immune …
immune response which may contribute towards development of accelerated immune …
Natural history, clinical manifestations, and pathogenesis of hepatitis A
EC Shin, SH Jeong - Cold Spring Harbor …, 2018 - perspectivesinmedicine.cshlp.org
Hepatitis A virus (HAV) is transmitted by the fecal–oral route and is a major cause of acute
viral hepatitis. The clinical manifestations of HAV infection range from asymptomatic …
viral hepatitis. The clinical manifestations of HAV infection range from asymptomatic …
Revealing the role of CD4+ T cells in viral immunity
AJ Sant, A McMichael - Journal of Experimental Medicine, 2012 - rupress.org
Protective immunity to chronic and acute viral infection relies on both the innate and
adaptive immune response. Although neutralizing antibody production by B cells and …
adaptive immune response. Although neutralizing antibody production by B cells and …