Advanced neurotechnologies for the restoration of motor function

S Micera, M Caleo, C Chisari, FC Hummel, A Pedrocchi - Neuron, 2020 - cell.com
Stroke is one of the leading causes of long-term disability. Advanced technological solutions
(" neurotechnologies") exploiting robotic systems and electrodes that stimulate the nervous …

Preclinical upper limb neurorobotic platform to assess, rehabilitate, and develop therapies

M Pasquini, ND James, I Dewany, FV Coen, N Cho… - Science Robotics, 2022 - science.org
Numerous neurorehabilitative, neuroprosthetic, and repair interventions aim to address the
consequences of upper limb impairments after neurological disorders. Although these …

Experimental and computational study on motor control and recovery after stroke: toward a constructive loop between experimental and virtual embodied …

AL Allegra Mascaro, E Falotico, S Petkoski… - Frontiers in systems …, 2020 - frontiersin.org
Being able to replicate real experiments with computational simulations is a unique
opportunity to refine and validate models with experimental data and redesign the …

Combining optogenetic stimulation and motor training improves functional recovery and perilesional cortical activity

E Conti, A Scaglione, G de Vito… - … and Neural Repair, 2022 - journals.sagepub.com
Background. An ischemic stroke is followed by the remapping of motor representation and
extensive changes in cortical excitability involving both hemispheres. Although stimulation of …

Automated home cage training of mice in a hold-still center-out reach task

T Bollu, SC Whitehead, N Prasad… - Journal of …, 2019 - journals.physiology.org
An obstacle to understanding neural mechanisms of movement is the complex, distributed
nature of the mammalian motor system. Here we present a novel behavioral paradigm for …

Fast-spiking interneurons of the premotor cortex contribute to initiation and execution of spontaneous actions

N Giordano, C Alia, L Fruzzetti, M Pasquini… - Journal of …, 2023 - Soc Neuroscience
Planning and execution of voluntary movement depend on the contribution of distinct
classes of neurons in primary motor and premotor areas. However, timing and pattern of …

Cortical propagation tracks functional recovery after stroke

G Cecchini, A Scaglione… - PLoS Computational …, 2021 - journals.plos.org
Stroke is a debilitating condition affecting millions of people worldwide. The development of
improved rehabilitation therapies rests on finding biomarkers suitable for tracking functional …

Restoration of motor-evoked cortical activity is a distinguishing feature of the most effective rehabilitation therapy after stroke

E Conti, ALA Mascaro, A Scaglione, G de Vito, F Calugi… - bioRxiv, 2020 - biorxiv.org
Background An ischemic stroke is followed by the remapping of motor representation and
extensive changes in cortical excitability involving both hemispheres. Although stimulation of …

[HTML][HTML] Combining robotics with enhanced serotonin-driven cortical plasticity improves post-stroke motor recovery

S Conti, C Spalletti, M Pasquini, N Giordano… - Progress in …, 2021 - Elsevier
Despite recent progresses in robotic rehabilitation technologies, their efficacy for post-stroke
motor recovery is still limited. Such limitations might stem from the insufficient enhancement …

Early, sustained and broadly-tuned discharge of fast-spiking interneurons in the premotor cortex during action planning

NC Giordano - 2021 - ricerca.sns.it
Preparatory neural activity in premotor areas is critical for planning and execution of
voluntary movements. Previous studies in monkeys and mice have revealed how the …