A vaccine for human babesiosis: Prospects and feasibility

H Al-Nazal, LM Low, S Kumar, MF Good… - Trends in Parasitology, 2022 - cell.com
Babesiosis is a tick-borne disease caused by intraerythrocytic Babesia parasites. It is a well-
known illness in companion animals and livestock, resulting in substantial economic losses …

Updated List of Transport Proteins in Plasmodium falciparum

J Wunderlich - Frontiers in Cellular and Infection Microbiology, 2022 - frontiersin.org
Malaria remains a leading cause of death and disease in many tropical and subtropical
regions of the world. Due to the alarming spread of resistance to almost all available …

Biochemical and cellular characterisation of the Plasmodium falciparum M1 alanyl aminopeptidase (PfM1AAP) and M17 leucyl aminopeptidase (PfM17LAP)

R Mathew, J Wunderlich, K Thivierge, K Cwiklinski… - Scientific Reports, 2021 - nature.com
The Plasmodium falciparum M1 alanyl aminopeptidase and M17 leucyl aminopeptidase, Pf
M1AAP and Pf M17LAP, are potential targets for novel anti-malarial drug development …

Cultivation of Asexual Intraerythrocytic Stages of Plasmodium falciparum

LK Basco - Pathogens, 2023 - mdpi.com
Successfully developed in 1976, the continuous in vitro culture of Plasmodium falciparum
has many applications in the field of malaria research. It has become an important …

Malaria proteomics: insights into the parasite–host interactions in the pathogenic space

JM Bautista, P Marín-García, A Diez, IG Azcárate… - Journal of …, 2014 - Elsevier
Proteomics is improving malaria research by providing global information on relevant
protein sets from the parasite and the host in connection with its cellular structures and …

Rapid expansion in the WAVE bioreactor of clinical scale cells for tumor immunotherapy

Y Meng, J Sun, T Hu, Y Ma, T Du, C Kong… - Human Vaccines & …, 2018 - Taylor & Francis
Cell-based immunotherapy using natural killer (NK) cells, cytokine-induced killer (CIK) cells
and dendritic cells (DCs) is emerging as a potential novel approach in the auxiliary …

A bioreactor system for the manufacture of a genetically modified Plasmodium falciparum blood stage malaria cell bank for use in a clinical trial

R Pawliw, R Farrow, S Sekuloski, H Jennings, J Healer… - Malaria journal, 2018 - Springer
Background Although the use of induced blood stage malaria infection has proven to be a
valuable tool for testing the efficacy of vaccines and drugs against Plasmodium falciparum, a …

The development of sexual stage malaria gametocytes in a Wave Bioreactor

CG Demanga, JWL Eng, DL Gardiner, A Roth… - Parasites & vectors, 2017 - Springer
Background Blocking malaria gametocyte development in RBCs or their fertilization in the
mosquito gut can prevent infection of the mosquito vector and passage of disease to the …

Investigating a Plasmodium falciparum erythrocyte invasion phenotype switch at the whole transcriptome level

PB Nyarko, SJ Tarr, Y Aniweh, LB Stewart… - Scientific reports, 2020 - nature.com
The central role that erythrocyte invasion plays in Plasmodium falciparum survival and
reproduction makes this process an attractive target for therapeutic or vaccine development …

Putrescine: Essential factor for in vitro proliferation of Babesia bovis

C Rojas-Martínez, RI Rodríguez-Vivas… - Experimental …, 2017 - Elsevier
This study reports the effect of putrescine addition, either alone or in combination with
insulin, transferrin and selenite (ITS), to serum-free Advanced DMEM/F12 (A-DMEM/F12) …