Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

Integrins, and integrin-mediated adhesions, have long been recognized to provide the main
molecular link attaching cells to the extracellular matrix (ECM) and to serve as bidirectional …

The complement system is deeply embedded in our physiology and immunity. Complement
activation generates a multitude of molecules that converge simultaneously on the …

Integrins are large, membrane-spanning, heterodimeric proteins that are essential for a
metazoan existence. All members of the integrin family adopt a shape that resembles a large …

In their roles as major adhesion receptors, integrins signal across the plasma membrane in
both directions. Recent structural and cell biological data suggest models for how integrins …

▪ Abstract Proteins that contain the Arg-Gly-Asp (RGD) attachment site, together with the
integrins that serve as receptors for them, constitute a major recognition system for cell …

Cell adhesion is crucial for the assembly of individual cells into the three-dimensional
tissues of animals. Cells do not simply “stick” together to form tissues, but rather are …

The integrin family of transmembrane adhesion receptors is essential for sensing and
adhering to the extracellular environment. Integrins are heterodimers composed of non …

Von Willebrand factor (VWF) is a blood glycoprotein that is required for normal hemostasis,
and deficiency of VWF, or von Willebrand disease (VWD), is the most common inherited …

Integrins are cell adhesion molecules that mediate cell-cell, cell–extracellular matrix, and
cell-pathogen interactions. They play critical roles for the immune system in leukocyte …