Astrocytes in human central nervous system diseases: a frontier for new therapies

A Verkhratsky, A Butt, B Li, P Illes, R Zorec… - … and Targeted Therapy, 2023 - nature.com
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

Neuroinflammation in Alzheimer's disease

IG Onyango, GV Jauregui, M Čarná, JP Bennett Jr… - Biomedicines, 2021 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disease associated with human aging.
Ten percent of individuals over 65 years have AD and its prevalence continues to rise with …

Autophagy and apoptosis cascade: which is more prominent in neuronal death?

R Gupta, RK Ambasta, P Kumar - Cellular and molecular life sciences, 2021 - Springer
Autophagy and apoptosis are two crucial self-destructive processes that maintain cellular
homeostasis, which are characterized by their morphology and regulated through signal …

Applications of fluorine-containing amino acids for drug design

H Mei, J Han, KD Klika, K Izawa, T Sato… - European journal of …, 2020 - Elsevier
Fluorine-containing amino acids are becoming increasingly prominent in new drugs due to
two general trends in the modern pharmaceutical industry. Firstly, the growing acceptance of …

Astrocytes in Alzheimer's disease: pathological significance and molecular pathways

P Preman, M Alfonso-Triguero, E Alberdi… - Cells, 2021 - mdpi.com
Astrocytes perform a wide variety of essential functions defining normal operation of the
nervous system and are active contributors to the pathogenesis of neurodegenerative …

Astroglial atrophy in Alzheimer's disease

A Verkhratsky, JJ Rodrigues, A Pivoriunas… - … -European Journal of …, 2019 - Springer
Astrocytes, a class of morphologically and functionally diverse primary homeostatic
neuroglia, are key keepers of neural tissue homeostasis and fundamental contributors to …

Mesenchymal stem cell-derived exosomal miR-223 regulates neuronal cell apoptosis

H Wei, Y Xu, Q Chen, H Chen, X Zhu, Y Li - Cell death & disease, 2020 - nature.com
Hypoxia limits the survival and function of neurons in the development of Alzheimer's
diseases. Exosome-dependent intercellular communication is an emerging signaling …

[HTML][HTML] Gut microbiota and its metabolites: bridge of dietary nutrients and Alzheimer's disease

G Zhu, J Zhao, H Zhang, G Wang, W Chen - Advances in Nutrition, 2023 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
cognitive impairment and neuroinflammation. Recent research has revealed the crucial role …

Role of the metabolism of branched-chain amino acids in the development of Alzheimer's disease and other metabolic disorders

B Polis, AO Samson - Neural regeneration research, 2020 - journals.lww.com
Alzheimer's disease is an incurable chronic neurodegenerative disorder and the leading
cause of dementia, imposing a growing economic burden upon society. The disease …

[HTML][HTML] The role of microglia immunometabolism in neurodegeneration: Focus on molecular determinants and metabolic intermediates of metabolic reprogramming

Q Wang, M Lu, X Zhu, X Gu, T Zhang, C Xia… - Biomedicine & …, 2022 - Elsevier
Microglia, resident macrophages that act as the brain's innate immune cells, play a key role
in initiating a defense response to the infection or neuroinflammation of the host. Once a …