The endothelial-to-mesenchymal transition (EMT) of glomerular vascular endothelial cells is
considered to be pivotal in diabetic nephropathy (DN). The risk of DN can be decreased by …

Atherosclerosis is a multifactorial condition characterized by endothelial injury, fatty streak
deposition, and stiffening of the blood vessels. The pathogenesis is complex and mediated …

In this work, we sought to generate sustained-release injectable microspheres loaded with
the GLP-1 analogue liraglutide. Using water-in-oil-in-water double emulsion methods, poly …

Diabetic nephropathy is one of the most common causes of end-stage kidney disease.
Aldosterone and angiotensin II appear to play a crucial role in the pathogenesis of this …

Endothelial dysfunction is a critical factor during the initiation of diabetic cardiovascular
complications and angiotensin II appears to play a pivotal role in this setting. The present …

Pumpkin polysaccharide (PPe-H) can perform physiological functions through its
antioxidative and hypoglycemic effects; however, the mechanisms through which PPe-H …

Diabetic dyslipidemia is a significant contributor in the pathogenesis of type 2 diabetes
(T2D). The study aimed at comparing the effect of dapagliflozin, liraglutide, and atorvastatin …

Abstract Background The 12-lipoxygenase (12-LO) and angiotensin II (Ang II) interaction
plays an important role in diabetic nephropathy (DN). Proteinuria in DN is associated with …

Dysfunction of perivascular adipose tissue of mesenteric bed participates in the
pathophysiology of high blood pressure linked to metabolic syndrome. Thus, it might …

The administration of statin might increase the risk of new-onset diabetes in
hypercholesterolemic patients based on the recent clinical evidence. However, the causal …