The presented review is an attempt to summarize a huge volume of data on 5-ene-4-
thiazolidinones being a widely studied class of small molecules used in modern organic and …

Rhodanines, thiazolidine-2, 4-diones and pseudothiohydantoins have become a very
interesting class of heterocyclic compounds since the introduction of various glitazones and …

The histone acetyltransferase (HAT) p300/CBP is a transcriptional coactivator implicated in
many gene regulatory pathways and protein acetylation events. Although p300 inhibitors …

Introduction: Rhodanines, as one of the 4-thiazolidinones subtypes, are recognized as
privileged heterocycles in medicinal chemistry. The main achievements include the …

Computational screening of databases has become increasingly popular in the
pharmaceutical research. Virtual screening uses computer based methods to discover new …

Abstract Several rhodanine derivatives (9–39) were synthesized for evaluation of their
potential as anticancer agents. Villsmeier cyclization to synthesize aza-aromatic aldehydes …

The poly (ADP-ribose)(PAR) post-translational modification is essential for diverse cellular
functions, including regulation of transcription, response to DNA damage, and mitosis …

The plant melatonin biosynthetic pathway has been well characterized, but inhibitors of
melatonin synthesis have not been well studied. Here, we found that flavonoids potently …

Lysine acetylation is a major post-translational modification in histones and other proteins
that is catalysed by the 'writer'lysine acetyltransferases (KATs) and mediates interactions …

Histone acetyltransferases (HATs) are promising epigenetic drug targets and are involved in
the pathogenesis of a wide range of diseases. We carried out a virtual screening based on …