The exploitation of host autophagy and ubiquitin machinery by Mycobacterium tuberculosis in shaping immune responses and host defense during infection
Intracellular pathogens have evolved various efficient molecular armaments to subvert
innate defenses. Cellular ubiquitination, a normal physiological process to maintain …
innate defenses. Cellular ubiquitination, a normal physiological process to maintain …
DNA methyltransferases: from evolution to clinical applications
VM Del Castillo Falconi, K Torres-Arciga… - International journal of …, 2022 - mdpi.com
DNA methylation is an epigenetic mark that living beings have used in different
environments. The MTases family catalyzes DNA methylation. This process is conserved …
environments. The MTases family catalyzes DNA methylation. This process is conserved …
The M. tuberculosis Rv1523 Methyltransferase Promotes Drug Resistance Through Methylation-Mediated Cell Wall Remodeling and Modulates Macrophages …
The acquisition of antibiotics resistance is a major clinical challenge limiting the effective
prevention and treatment of the deadliest human infectious disease tuberculosis. The …
prevention and treatment of the deadliest human infectious disease tuberculosis. The …
Protein adaptations in extremophiles: an insight into extremophilic connection of mycobacterial proteome
The biological paradox about how extremophiles persist at extreme ecological conditions
throws a fascinating picture of the enormous potential of a single cell to adapt to homeostatic …
throws a fascinating picture of the enormous potential of a single cell to adapt to homeostatic …
Proteome Profiling of Mycobacterium tuberculosis Cells Exposed to Nitrosative Stress
Reactive nitrogen species (RNS) are secreted by human cells in response to infection by
Mycobacterium tuberculosis (Mtb). Although RNS can kill Mtb under some circumstances …
Mycobacterium tuberculosis (Mtb). Although RNS can kill Mtb under some circumstances …
Post translational modifications in tuberculosis: ubiquitination paradox
Innate immune signaling and xenophagy are crucial innate defense strategies exploited by
the host to counteract intracellular pathogens with ubiquitination as a critical regulator of …
the host to counteract intracellular pathogens with ubiquitination as a critical regulator of …
Mycobacterium tuberculosis Methyltransferase Rv1515c Can Suppress Host Defense Mechanisms by Modulating Immune Functions Utilizing a Multipronged …
Mycobacterium tuberculosis (M. tb) gene Rv1515c encodes a conserved hypothetical
protein exclusively present within organisms of MTB complex and absent in non-pathogenic …
protein exclusively present within organisms of MTB complex and absent in non-pathogenic …
[HTML][HTML] TN strain proteome mediated therapeutic target mapping and multi-epitopic peptide-based vaccine development for Mycobacterium leprae
Leprosy is a significant universal health problem that is remarkably still a concern in
developing countries due to infection frequency. New therapeutic molecules and next …
developing countries due to infection frequency. New therapeutic molecules and next …
[HTML][HTML] Forensic epigenetic analysis: the path ahead
S Sabeeha, SE Hasnain - Medical principles and practice, 2019 - karger.com
Unlike DNA fingerprinting, which scores for differences in the genome that are phenotype
neutral, epigenetic variations are gaining importance in forensic investigations. Methylation …
neutral, epigenetic variations are gaining importance in forensic investigations. Methylation …
Expression of a unique M. tuberculosis DNA MTase Rv1509 in M. smegmatis alters the gene expression pattern and enhances virulence
P Manjunath, J Ahmad, J Samal, A Rani… - Frontiers in …, 2024 - frontiersin.org
Mycobacterium tuberculosis (M. tb) genome encompasses 4,173 genes, about a quarter of
which remain uncharacterized and hypothetical. Considering the current limitations …
which remain uncharacterized and hypothetical. Considering the current limitations …