Ablation modalities for therapeutic intervention in arrhythmia-related cardiovascular disease: focus on electroporation

S McBride, S Avazzadeh, AM Wheatley… - Journal of Clinical …, 2021 - mdpi.com
Targeted cellular ablation is being increasingly used in the treatment of arrhythmias and
structural heart disease. Catheter-based ablation for atrial fibrillation (AF) is considered a …

Effects of electrode-tissue proximity on cardiac lesion formation using pulsed field ablation

B Howard, A Verma, WS Tzou, L Mattison… - Circulation …, 2022 - Am Heart Assoc
Background: Pulsed field ablation (PFA) is a novel energy modality for treatment of cardiac
arrhythmias. The impact of electrode-tissue proximity on lesion formation by PFA has not …

Opportunities and challenges in catheter-based irreversible electroporation for ventricular tachycardia

ML Repp, IR Chinyere - Pathophysiology, 2024 - mdpi.com
The use of catheter-based irreversible electroporation in clinical cardiac laboratories, termed
pulsed-field ablation (PFA), is gaining international momentum among cardiac …

Surgical ablation of cardiac tissue with nanosecond pulsed electric fields in swine

F Varghese, JM Philpott, JU Neuber… - Cardiovascular …, 2023 - Springer
Background Myocardial tissue can be ablated by the application nanosecond pulsed fields
(nsPEFs). The applied electric fields irreversibly permeabilize cell membranes and thereby …

A computational model of open‐irrigated radiofrequency catheter ablation accounting for mechanical properties of the cardiac tissue

A Petras, M Leoni, JM Guerra, J Jansson… - International Journal …, 2019 - Wiley Online Library
Radiofrequency catheter ablation (RFCA) is an effective treatment for cardiac arrhythmias.
Although generally safe, it is not completely exempt from the risk of complications. The great …

A transversely isotropic thermo-hyperelastic constitutive model of myocardial tissue with a three-state cell death dynamics for cardiac radiofrequency ablation

L Molinari, L Gerardo-Giorda, A Gizzi - … of the Mechanics and Physics of …, 2022 - Elsevier
Constitutive models of radiofrequency catheter ablation (RFCA) lack a reliable three-
dimensional microstructural representation of the myocardium. Besides, complex …

Human in vitro assay for irreversible electroporation cardiac ablation

M Casciola, TK Feaster, MJ Caiola, D Keck… - Frontiers in …, 2023 - frontiersin.org
Introduction: Pulsed electric field (PEF) cardiac ablation has been recently proposed as a
technique to treat drug resistant atrial fibrillation by inducing cell death through irreversible …

Effect of anisotropic electrical conductivity induced by fiber orientation on ablation characteristics of pulsed field ablation in atrial fibrillation treatment: a computational …

L Zang, K Gu, X Ji, H Zhang, S Yan, X Wu - Journal of Cardiovascular …, 2022 - mdpi.com
Pulsed field ablation (PFA) is a promising new ablation modality for the treatment of atrial
fibrillation (AF); however, the effect of fiber orientation on the ablation characteristics of PFA …

Analysis of electrostimulation and electroporation by high repetition rate bursts of nanosecond stimuli

EB Sözer, AG Pakhomov, I Semenov, M Casciola… - …, 2021 - Elsevier
Exposures to short-duration, strong electric field pulses have been utilized for stimulation,
ablation, and the delivery of molecules into cells. Ultrashort, nanosecond duration pulses …

[HTML][HTML] Determination of lethal electric field threshold for pulsed field ablation in ex vivo perfused porcine and human hearts

B Kos, L Mattison, D Ramirez, H Cindrič… - Frontiers in …, 2023 - frontiersin.org
Introduction Pulsed field ablation is an emerging modality for catheter-based cardiac
ablation. The main mechanism of action is irreversible electroporation (IRE), a threshold …