Less than a decade ago, it was shown that bromodomains, acetyl lysine 'reader'modules
found in proteins with varied functions, were highly tractable small-molecule targets. This is …

The bromodomain acts to recognize acetylated lysine in histones and transcription proteins
and plays a fundamental role in chromatin-based cellular processes including gene …

Bromodomains (BRDs) are conserved protein interaction modules which recognize (read)
acetyl-lysine modifications, however their role (s) in regulating cellular states and their …

With the bromodomain (BRD) inhibitor JQ1, a remarkable success story of BRD4 as a novel
drug target has been set off that yielded many anti‐cancer drugs that are now in clinical …

The development of taxane resistance remains a major challenge for castration resistant
prostate cancer (CR-PCa), despite the effectiveness of taxanes in prolonging patient …

Simple Summary This review provides an in depth analysis of the role of bromodomain-
containing proteins in cancer development. As readers of acetylated lysine on nucleosomal …

The bone tissue is a dynamic complex that constitutes of several interdependent systems
and is continuously remodeled through the concerted actions of bone cells. Osteoblasts are …

Epigenetic deregulation plays an essential role in hepatocellular carcinoma (HCC)
progression. Bromodomains are epigenetic “readers” of histone acetylation. Recently …

Bromodomain-containing proteins include bromodomain and extra-terminal (BET) and non-
BET families. Due to the conserved bromodomain (BD) module between BD-containing …

The reading of acetylation marks on histones by bromodomain (BRD) proteins is a key event
in transcriptional activation. Small molecule inhibitors targeting bromodomain and extra …