High-throughput methods in the discovery and study of biomaterials and materiobiology

L Yang, S Pijuan-Galito, HS Rho, AS Vasilevich… - Chemical …, 2021 - ACS Publications
The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …

[HTML][HTML] Biomaterial-induced pathway modulation for bone regeneration

S Vermeulen, ZT Birgani, P Habibovic - Biomaterials, 2022 - Elsevier
Embryogenic developmental processes involve a tightly controlled regulation between
mechanical forces and biochemical cues such as growth factors, matrix proteins, and …

Manipulation of stem cells fates: the master and multifaceted roles of biophysical cues of biomaterials

X Wan, Z Liu, L Li - Advanced Functional Materials, 2021 - Wiley Online Library
Owing to their self‐renewal and differentiation ability, stem cells are conducive for repairing
injured tissues, making them a promising source of seed cells for tissue engineering. The …

Nanofiber arrangement regulates peripheral nerve regeneration through differential modulation of macrophage phenotypes

Y Jia, W Yang, K Zhang, S Qiu, J Xu, C Wang, Y Chai - Acta Biomaterialia, 2019 - Elsevier
Topographical cues presented by aligned nanofibers have been demonstrated to stimulate
peripheral nerve regeneration across long gaps, but the underlying mechanisms remain …

Intrinsic mechanical cues and their impact on stem cells and embryogenesis

J Petzold, E Gentleman - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Although understanding how soluble cues direct cellular processes revolutionised the study
of cell biology in the second half of the 20th century, over the last two decades, new insights …

Modulating the foreign body response of implants for diabetes treatment

BN Kharbikar, GS Chendke, TA Desai - Advanced drug delivery reviews, 2021 - Elsevier
Diabetes Mellitus is a group of diseases characterized by high blood glucose levels due to
patients' inability to produce sufficient insulin. Current interventions often require implants …

Delivering mechanical stimulation to cells: state of the art in materials and devices design

Y Zhang, P Habibovic - Advanced Materials, 2022 - Wiley Online Library
Biochemical signals, such as growth factors, cytokines, and transcription factors are known
to play a crucial role in regulating a variety of cellular activities as well as maintaining the …

A blueprint of the topology and mechanics of the human ovary for next-generation bioengineering and diagnosis

E Ouni, A Peaucelle, KT Haas, O Van Kerk… - Nature …, 2021 - nature.com
Although the first dissection of the human ovary dates back to the 17th century, the
biophysical characteristics of the ovarian cell microenvironment are still poorly understood …

The effect of physical cues of biomaterial scaffolds on stem cell behavior

S Wang, S Hashemi, S Stratton… - Advanced Healthcare …, 2021 - Wiley Online Library
Stem cells have been sought as a promising cell source in the tissue engineering field due
to their proliferative capacity as well as differentiation potential. Biomaterials have been …

High-throughput routes to biomaterials discovery

F Soheilmoghaddam, M Rumble… - Chemical …, 2021 - ACS Publications
Many existing clinical treatments are limited in their ability to completely restore decreased
or lost tissue and organ function, an unenviable situation only further exacerbated by a …