Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application

X Zhao, J Liu, J Fan, H Chao, X Peng - Chemical Society Reviews, 2021 - pubs.rsc.org
Photodynamic therapy (PDT), a therapeutic mode involving light triggering, has been
recognized as an attractive oncotherapy treatment. However, nonnegligible challenges …

Visible-to-NIR-light activated release: from small molecules to nanomaterials

R Weinstain, T Slanina, D Kand, P Klan - Chemical reviews, 2020 - ACS Publications
Photoactivatable (alternatively, photoremovable, photoreleasable, or photocleavable)
protecting groups (PPGs), also known as caged or photocaged compounds, are used to …

Phthalocyanines as medicinal photosensitizers: Developments in the last five years

X Li, BD Zheng, XH Peng, SZ Li, JW Ying… - Coordination Chemistry …, 2019 - Elsevier
Owing to their high extinction coefficients, long absorption wavelengths, and modification
tunable photophysical and photochemical properties, phthalocyanines (Pcs) have been …

Near-infrared photoactivatable nitric oxide donors with integrated photoacoustic monitoring

EY Zhou, HJ Knox, CJ Reinhardt… - Journal of the …, 2018 - ACS Publications
Photoacoustic (PA) tomography is a noninvasive technology that utilizes near-infrared (NIR)
excitation and ultrasonic detection to image biological tissue at centimeter depths. While …

Conjugates of porphyrinoid-based photosensitizers with cytotoxic drugs: current progress and future directions toward selective photodynamic therapy

VF Otvagin, NS Kuzmina, ES Kudriashova… - Journal of medicinal …, 2022 - ACS Publications
Photodynamic therapy (PDT) is a treatment modality where light-mediated activation of
photosensitizers in a patient's body leads to the generation of cytotoxic reactive oxygen …

A review on gold nanoclusters for cancer phototherapy

Z Yang, X Yang, Y Guo, H Kawasaki - ACS Applied Bio Materials, 2023 - ACS Publications
Cancer phototherapy, including photodynamic therapy (PDT) and photothermal therapy
(PTT), has been extensively studied in recent years because of its noninvasive properties …

Spatiotemporal control of biology: Synthetic photochemistry toolbox with far-red and near-infrared light

S Jia, EM Sletten - ACS chemical biology, 2021 - ACS Publications
The complex network of naturally occurring biological pathways motivates the development
of new synthetic molecules to perturb and/or detect these processes for fundamental …

Near infrared light-triggered nanoparticles using singlet oxygen photocleavage for drug delivery systems

CG Dariva, JFJ Coelho, AC Serra - Journal of Controlled Release, 2019 - Elsevier
Drug delivery systems (DDSs) have showed a reduced systemic toxicity and enhanced
therapeutic efficacy over conventional cancer treatments. However, after reaching the …

Light-responsive prodrug-based supramolecular nanosystems for site-specific combination therapy of cancer

SZF Phua, C Xue, WQ Lim, G Yang, H Chen… - Chemistry of …, 2019 - ACS Publications
On-demand release of chemotherapeutic drugs from their prodrugs triggered by light
irradiation has been attracting great attention for effective cancer treatment. Herein, we …

Prodrug strategies for targeted therapy triggered by reactive oxygen species

JP Cadahía, V Previtali, NS Troelsen, MH Clausen - MedChemComm, 2019 - pubs.rsc.org
Increased levels of reactive oxygen species (ROS) have been associated with numerous
pathophysiological conditions including cancer and inflammation and the ROS stimulus …