Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …

Myelin is a multilayer lipid membrane structure that wraps and insulates axons, allowing for
the efficient propagation of action potentials. During developmental myelination of the …

Myelinated nerve fibers are essential for the rapid propagation of action potentials by
saltatory conduction. They form as the result of reciprocal interactions between axons and …

Despite the importance of myelin for the rapid conduction of action potentials, the molecular
bases of oligodendrocyte differentiation and central nervous system (CNS) myelination are …

In the peripheral nervous system, Schwann cells are glial cells that are in intimate contact
with axons throughout development. Schwann cells generate the insulating myelin sheath …

The NFAT (nuclear factor of activated T cells) family of transcription factors consists of four
Ca 2+-regulated members (NFAT1–NFAT4), which were first described in T lymphocytes. In …

Parkinson's disease-associated kinase LRRK2 has been linked to IFN type II (IFN-γ)
response in infections and to dopaminergic neuronal loss. However, whether and how …

Leucine-rich repeat kinase 2 (LRRK2) has been identified by genome-wide association
studies as being encoded by a major susceptibility gene for Crohn's disease. Here we found …

Myelin is essential to nervous system function, playing roles in saltatory conduction and
trophic support. Oligodendrocytes (OLs) and Schwann cells (SCs) form myelin in the central …

The AP-1 transcription factor c-Jun is a master regulator of the axonal response in neurons.
c-Jun also functions as a negative regulator of myelination in Schwann cells (SCs) and is …