This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

Since the discovery nearly 60 years ago, cAMP is envisioned as one of the most universal
and versatile second messengers. The tremendous feature of cAMP to tightly control highly …

Fibrosis, the result of excess deposition of extracellular matrix (ECM), in particular collagen,
leads to scarring and loss of function in tissues that include the heart, lung, kidney and liver …

Chronic degenerative inflammatory diseases, such as chronic obstructive pulmonary
disease and Alzheimer's dementia, afflict millions of people around the world, causing death …

Aims/hypothesis In adults, circulating inflammatory mediators and activated CD14++
monocytes link obesity to its metabolic and cardiovascular complications. However, it is …

Scar formation occurs during the late stages of the inflammatory response but, when
excessive, produces fibrosis that can lead to functional and structural damage of tissues …

Epac proteins respond to the second messenger cyclic AMP (cAMP) and are activated by Gs
coupled receptors. They act as specific guanine nucleotide exchange factors (GEFs) for the …

Transforming growth factor-β (TGF-β) plays a pivotal role in a range of biological processes,
including the control of cellular proliferation and differentiation, regulation of tissue repair …

The establishment of a Gordon Research Conference devoted to cyclic nucleotide
phosphodiesterases has had an enormous impact on the field by facilitating collaborations …

Research during the past 15 years has led to significant breakthroughs, providing evidence
of a high degree of similarity between insect and mammalian innate immune responses …