The influence of meal frequency and timing on health and disease has been a topic of
interest for many years. While epidemiological evidence indicates an association between …

Sodium-glucose cotransporter-2 (SGLT2) inhibitors, including empagliflozin, dapagliflozin,
and canagliflozin, are now widely approved antihyperglycemic therapies. Because of their …

The progressive increase in lifespan over the past century carries with it some adversity
related to the accompanying burden of debilitating diseases prevalent in the older …

Western societies are aging due to an increasing life span, decreased birth rates, and
improving social and health conditions. On the other hand, the prevalence of cardiovascular …

Although ischemic heart disease is the major cause of death in diabetic patients, diabetic
cardiomyopathy (DCM) is increasingly recognized as a clinically relevant entity. Considering …

Aims A diet with modified components, such as a ketogenic low-carbohydrate (LC) diet,
potentially extends longevity and healthspan. However, how an LC diet impacts on cardiac …

摘要活性氧以及活性氮(Reactive oxygen species, ROS; Reactive nitrogen species, RNS)
是细胞中间营养物质生理代谢过程中的副产品. 虽然生理防御机制可以迅速将这类物资转化成水 …

Calorie restriction (CR) increases average and maximum lifespan and exhibits an apparent
beneficial impact on age‐related diseases. Several studies have shown that CR initiated …

Obesity and hyperinsulinemia are risk factors for stroke. We tested the hypothesis that
caloric restriction, which reduces the incidence of age‐related obesity and metabolic …

The circadian clock refers to the intrinsic biological rhythms of physiological functions and
behaviours. It synergises with the solar cycle and has profound effects on normal …