A rapidly emerging field in lab-on-a-chip (LOC) research is the development of devices to
improve the health of people in developing countries. In this review, we identify diseases …

Despite a growing focus from the academic community, the field of microfluidics has yet to
produce many commercial devices for point-of-care (POC) diagnostics. One of the main …

Background Tuberculosis remains an important cause of death among patients infected with
the human immunodeficiency virus (HIV). Robust data are lacking with regard to the timing …

Human antibodies to human immunodeficiency virus-1 (HIV-1) can neutralize a broad range
of viral isolates in vitro and protect non-human primates against infection,. Previous work …

Long-term in vivo expression of a broad and potent entry inhibitor could circumvent the need
for a conventional vaccine for HIV-1. Adeno-associated virus (AAV) vectors can stably …

CCR5 is the major HIV-1 co-receptor, and individuals homozygous for a 32-bp deletion in
CCR5 are resistant to infection by CCR5-tropic HIV-1. Using engineered zinc-finger …

Biomarkers are essential tools in clinical research and practice. Useful biomarkers must
combine good measurability, validated association with biological processes or outcomes …

Detecting and quantifying biomarkers and viruses in biological samples have broad
applications in early disease diagnosis and treatment monitoring. We have demonstrated a …

Although it is a standard practice in high-income countries, determination of the human
immunodeficiency virus (HIV) load is not recommended in developing countries because of …

Lateral flow assays (LFAs) as rapid analytical techniques promise to be widely used in point-
of-care (POC) diagnostics because of their affordability and simplicity. However, LFAs still …