Many patients with chest pain undergoing coronary angiography do not show significant
obstructive coronary lesions. A substantial proportion of these patients have abnormalities in …

The endothelium is composed of a monolayer of endothelial cells, lining the interior surface
of blood and lymphatic vessels. Endothelial cells display important homeostatic functions …

Heart failure is a clinical syndrome where cardiac output is not sufficient to sustain adequate
perfusion and normal bodily functions, initially during exercise and in more severe forms …

Heart failure (HF) prevalence remains high worldwide with significant sex-related and
regional differences in its presentation, management, and outcomes. In 2020, advances in …

Objectives The purpose of this study was to evaluate the prognostic value of quantitative
myocardial blood flow (MBF) and myocardial flow reserve (MFR), reflecting the integrated …

Inflammation is a key determinant of cardiovascular outcomes, but its role in heart failure is
uncertain. In patients with cardiometabolic disease enrolled in the prospective, multicenter …

In heart failure with reduced ejection fraction (HFrEF), diminished tonic and reflex vagal
heart rate modulation and exaggerated sympathetic outflow and neural norepinephrine …

Background and aims Triglyceride and glycose (TyG) index has been viewed as a reliable
surrogate of cardiovascular disease (CVD) risk. We hypothesized that elevated TyG index is …

Importance Impaired myocardial flow reserve (MFR) and stress myocardial blood flow (MBF)
on positron emission tomography (PET) myocardial perfusion imaging may identify adverse …

Coronary microvascular dysfunction (CMD) is a clinical entity linked with various risk factors
that significantly affect cardiac morbidity and mortality. Hypertension, one of the most …