Less than a decade ago, it was shown that bromodomains, acetyl lysine 'reader'modules
found in proteins with varied functions, were highly tractable small-molecule targets. This is …

Aberrations in the epigenetic landscape are a hallmark of cancer. Alterations in enzymes
that are “writers,”“erasers,” or “readers” of histone modification marks are common …

Low high-density lipoprotein cholesterol (HDL-C) characterizes an atherogenic dyslipidemia
that reflects adverse lifestyle choices, impaired metabolism, and increased cardiovascular …

Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA
modification, histone modification, RNA modification, chromatin remodeling, and non-coding …

Coronary artery disease, the leading cause of death in the developed and developing
countries, is prevalent in diabetes mellitus with 68% cardiovascular disease (CVD)-related …

Epigenetics refers to heritable changes in gene expression patterns not caused by an
altered nucleotide sequence, and includes non-coding RNAs and covalent modifications of …

Aim To determine the effects of RVX‐208, a selective bromodomain and extra‐terminal
domain (BET) inhibitor targeting bromodomain 2 (BD2), on periodontal inflammation and …

Background After an acute coronary syndrome (ACS), patients with diabetes remain at high
risk for additional cardiovascular events despite use of current therapies. Bromodomain and …

Parasitic infections remain one of the most pressing global health concerns of our day,
affecting billions of people and producing unsustainable economic burdens. The rise of drug …

The homeostatic control of lipid metabolism is essential for many fundamental physiological
processes. A deep understanding of its regulatory mechanisms is pivotal to unravel …