I. Introduction D EATH, along with growth and differentiation, is a critical part of the life cycle
of a cell. Homeostatic control of cell number is thought to be the result of the dynamic …

The formation of distinct DNA fragments of oligonucleosomal size (180–200 by lengths) is a
biochemical hallmark of apoptosis in many cells. Recent observations also suggest large …

SPECIFICITY IN THE cAMP/PKA SIGNALING PATHWAY. DIFFERENTIAL EXPRESSION,
REGULATION, AND SUBCELLULAR LOCALIZATION OF SUBUNITS OF Page 1 [Frontiers in …

Purpose: Microtubules are important cytoskeletal components involved in many cellular
events. Antimicrotubule agents including polymerizing agents (paclitaxel and docetaxel) and …

The Bcl2 family of proteins plays a significant role in regulation of apoptosis. In this study, the
microtubule-damaging drugs paclitaxel, vincristine, and vinblastine induced Bcl2 …

Apoptosis or programmed cell death frequently parallels abnormalities in cell proliferation
and differentiation. As hypertrophy/hyperplasia or remodeling occurs in organs affected by …

Bordetella pertussis, the causative agent of whooping cough, has been shown recently to
enter and survive in epithelial cells and macrophages in vitro. In the present study, we show …

Okadaic acid, a specific and potent inhibitor of protein phosphatases 2A and 1, was tested
for its effect on the morphology of a number of cell types: freshly isolated rat hepatocytes in …

Novel (Rp)-cAMPS analogs differed widely in ability to antagonize cAMP activation of pure
cAMP-dependent protein kinase I and II and to antagonize actions of cAMP on gene …

Cyclic AMP (cAMP) has traditionally been thought to act exclusively through cAMP-
dependent protein kinase (cAPK, PKA), but a growing number of cAMP effects are not …