Global epidemiology of rheumatoid arthritis

A Finckh, B Gilbert, B Hodkinson, SC Bae… - Nature Reviews …, 2022 - nature.com
Rheumatoid arthritis (RA) is a systemic autoimmune disease that predominantly affects the
joints. The prevalence of RA varies globally, with generally a higher prevalence in …

Immunopathogenesis of rheumatoid arthritis

GS Firestein, IB McInnes - Immunity, 2017 - cell.com
Rheumatoid arthritis (RA) is the most common inflammatory arthropathy. The majority of
evidence, derived from genetics, tissue analyses, models, and clinical studies, points to an …

The immunopathogenesis of seropositive rheumatoid arthritis: from triggering to targeting

V Malmström, AI Catrina, L Klareskog - Nature Reviews Immunology, 2017 - nature.com
Patients with rheumatoid arthritis can be divided into two major subsets characterized by the
presence versus absence of antibodies to citrullinated protein antigens (ACPAs) and of …

Pathogenesis, clinical features, and treatment strategy for rheumatoid arthritis-associated interstitial lung disease

M Akiyama, Y Kaneko - Autoimmunity reviews, 2022 - Elsevier
Rheumatoid arthritis is an autoimmune disease that primarily affects the joints. The
emergence of highly effective anti-rheumatic drugs such as biologic agents and janus …

Immune modulation of some autoimmune diseases: the critical role of macrophages and neutrophils in the innate and adaptive immunity

KC Navegantes, R de Souza Gomes… - Journal of translational …, 2017 - Springer
Macrophages and neutrophils are key components involved in the regulation of numerous
chronic inflammatory diseases, infectious disorders, and especially certain autoimmune …

The pre-clinical phase of rheumatoid arthritis: from risk factors to prevention of arthritis

N Petrovská, K Prajzlerová, J Vencovský, L Šenolt… - Autoimmunity …, 2021 - Elsevier
Rheumatoid arthritis (RA) is a chronic autoimmune disease considered as a multistep
process spanning from the interaction of genetic (eg, shared epitope or non-HLA loci) …

Autoantibodies and B Cells: The ABC of rheumatoid arthritis pathophysiology

M Volkov, KA van Schie… - Immunological …, 2020 - Wiley Online Library
Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation. In
the last few decades, new insights into RA‐specific autoantibodies and B cells have greatly …

Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis

C Carmona-Rivera, PM Carlucci, E Moore… - Science …, 2017 - science.org
Rheumatoid arthritis (RA) is characterized by synovial joint inflammation and by
development of pathogenic humoral and cellular autoimmunity to citrullinated proteins …

Smoke and autoimmunity: The fire behind the disease

C Perricone, M Versini, D Ben-Ami, S Gertel… - Autoimmunity …, 2016 - Elsevier
The association between smoke habit and autoimmunity has been hypothesized a long time
ago. Smoke has been found to play a pathogenic role in certain autoimmune disease as it …

[PDF][PDF] Release of active peptidyl arginine deiminases by neutrophils can explain production of extracellular citrullinated autoantigens in rheumatoid arthritis synovial …

J Spengler, B Lugonja, A Jimmy Ytterberg… - Arthritis & …, 2015 - Wiley Online Library
Objective In the majority of patients with rheumatoid arthritis (RA), antibodies specifically
recognize citrullinated autoantigens that are generated by peptidylarginine deiminases …