Neural stem cells promote neuroplasticity: a promising therapeutic strategy for the treatment of Alzheimer's disease

J Chang, Y Li, X Shan, X Chen, X Yan… - Neural Regeneration …, 2024 - journals.lww.com
Recent studies have demonstrated that neuroplasticity, such as synaptic plasticity and
neurogenesis, exists throughout the normal lifespan but declines with age and is …

The role of resveratrol in neurogenesis: a systematic review

A Azargoonjahromi, F Abutalebian… - Nutrition …, 2025 - academic.oup.com
Context Resveratrol (RV) is a natural compound found in grapes, wine, berries, and peanuts
and has potential health benefits—namely, neurogenesis improvement. Neurogenesis …

SARS-CoV-2-Induced Type I Interferon Signaling Dysregulation in Olfactory Networks Implications for Alzheimer's Disease

GD Vavougios, T Mavridis, T Doskas… - Current Issues in …, 2024 - mdpi.com
Type I interferon signaling (IFN-I) perturbations are major drivers of COVID-19. Dysregulated
IFN-I in the brain, however, has been linked to both reduced cognitive resilience and …

[HTML][HTML] Characterization of age-and stage-dependent impaired adult subventricular neurogenesis in 5XFAD mouse model of Alzheimer's disease

HH Park, BH Kim, SH Leem, YH Park, HS Hoe… - BMB …, 2023 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
cognitive decline. Several recent studies demonstrated that impaired adult neurogenesis …

Current and emerging drug therapies in Alzheimer's disease: A pathophysiological Perspective

A Aparajita, U Jain, P Srivastava - Neuroscience, 2024 - Elsevier
The analytical and experimental investigation of several targets and biomarkers that help in
explaining significant cognitive deficits, covering drug development and precision medicine …

c-Cbl Regulates Murine Subventricular Zone-Derived Neural Progenitor Cells in Dependence of the Epidermal Growth Factor Receptor

M Vogt, MK Unnikrishnan, N Heinig, U Schumann… - Cells, 2023 - mdpi.com
The localization, expression, and physiological role of regulatory proteins in the neurogenic
niches of the brain is fundamental to our understanding of adult neurogenesis. This study …

Exercised-enriched blood plasma rescues hippocampal impairments and cognitive deficits in an Alzheimer's disease model

T Huang, X Gong, Z Liang, R Yang, L Wu… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, and moderate
exercise holds promise in ameliorating the ongoing neurodegeneration and cognitive …

Type I interferon signaling, cognition and neurodegeneration following COVID-19: update on a mechanistic pathogenetic model with implications for Alzheimer's …

GD Vavougios, VS Tseriotis, A Liampas… - Frontiers in Human …, 2024 - frontiersin.org
COVID-19's effects on the human brain reveal a multifactorial impact on cognition and the
potential to inflict lasting neuronal damage. Type I interferon signaling, a pathway that …

Emerging Pro-neurogenic Therapeutic Strategies for Neurodegenerative Diseases: A Review of Pre-clinical and Clinical Research

M Vassal, F Martins, B Monteiro, S Tambaro… - Molecular …, 2024 - Springer
The neuroscience community has largely accepted the notion that functional neurons can be
generated from neural stem cells in the adult brain, especially in two brain regions: the …

[HTML][HTML] 3D-bioprinted model of adult neural stem cell microenvironment in Alzheimer's disease

NDA Ferreira, PS Ferreira, CP Soares… - … Journal of Bioprinting, 2024 - accscience.com
Neurogenesis plays a major role in neuroplasticity and memory. In adult human and mouse
brains, neural stem cells (NSCs) are mainly distributed in two extensively characterized …