While much is known about the functional properties of cutaneous nociceptors, relatively
little is known about the comprehensive functional properties of group III and IV muscle …

Transient receptor potential vanilloid subtype 1 (TRPV1) is a polymodal nociceptor that
monitors noxious thermal sensations. Few studies have addressed the role of TRPV1 in …

Small fiber pathology is increasingly recognized as a potential contributor to neuropathic
pain in different clinical syndromes, however, the underlying mechanisms leading to …

Genetically modified Schwann cells (SCs) that overexpress neurotrophic factors (NFs),
especially those that overexpress multiple NFs, hold great potential for promoting nerve …

miRNAs play critical roles in various biological processes by targeting specific mRNAs.
Current approaches to identifying miRNA targets are insufficient for elucidation of a miRNA …

Osteoarthritis (OA) associated pain (OA-pain) is a significant global problem. OA-pain limits
limb use and mobility and is associated with widespread sensitivity. Therapeutic options are …

Burning mouth syndrome is characterized by altered sensory qualities, namely tongue pain
hypersensitivity. We found that the mRNA expression of Artemin (Artn) in the tongue mucosa …

Musculoskeletal pain is a significantly common clinical complaint. Although it is known that
muscles are quite sensitive to alterations in blood flow/oxygenation and a number of muscle …

It has been well documented that the transient receptor potential melastatin 8 (TRPM 8)
receptor is involved in environmental cold detection. The role that this receptor plays in …

The purinergic receptor P2Y1 modulates the thermal sensitivity of polymodal fibers and the
functional phenotype of TRPV1-containing cutaneous fibers following inflammation. We …