Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease worldwide.
ALD can progress from alcoholic fatty liver (AFL) to alcoholic steatohepatitis (ASH), which is …

Simple Summary Hepatocellular carcinoma (HCC) is a highly incident and deadly malignant
neoplasia, and only a few anti-HCC drugs are currently available. Thus, the development of …

The toxic properties of various nitrosamines in animals and humans are well established.
The parenteral or oral administration of the smallest quantities of diethylnitrosamine (DEN) …

The establishment of metabolic zonation within a hepatic lobule ascribes specific functions
to hepatocytes based on unique, location-dependent gene expression patterns. Recently …

The matricellular protein WISP1 is a member of the CCN protein family. It is induced by
WNT1 and is a downstream target of β-catenin. WISP1 is expressed during embryonic …

Highlights•GWAS suggest pathological inflammation is controlled by a small network of
genes.•Many chronic inflammatory/autoimmune risk alleles occur in regions of positive …

As a proliferative and restorative entity, Wnt1 inducible signaling pathway protein 1 (WISP1)
is emerging as a novel target for a number of therapeutic strategies that are relevant for …

Diabetes mellitus affects almost 350 million individuals throughout the globe resulting in
significant morbidity and mortality. Of further concern is the growing population of individuals …

The aim of this study is to understand the molecular mechanisms of N-nitrosodiethylamine
(NDEA) induced multi-organ carcinogenesis in tongue and liver of the same mouse and …

Circular ribonucleic acids (circRNAs) are non-coding RNAs of approximately 100
nucleotides in length with thousands of members in mammalian cells. The presence of …