RGD-binding integrins revisited: how recently discovered functions and novel synthetic ligands (re-) shape an ever-evolving field

BS Ludwig, H Kessler, S Kossatz, U Reuning - Cancers, 2021 - mdpi.com
Simple Summary Integrins, a superfamily of cell adhesion receptors, were extensively
investigated as therapeutic targets over the last decades, motivated by their multiple …

Biological and clinical consequences of integrin binding via a rogue RGD motif in the SARS CoV-2 spike protein

L Makowski, W Olson-Sidford, J W. Weisel - Viruses, 2021 - mdpi.com
Although ACE2 (angiotensin converting enzyme 2) is considered the primary receptor for
CoV-2 cell entry, recent reports suggest that alternative pathways may contribute. This paper …

The roles of integrin α5β1 in human cancer

J Hou, D Yan, Y Liu, P Huang, H Cui - OncoTargets and therapy, 2020 - Taylor & Francis
Cell adhesion to the extracellular matrix has important roles in tissue integrity and human
health. Integrins are heterodimeric cell surface receptors that are composed by two non …

[HTML][HTML] The challenges and opportunities of αvβ3-based therapeutics in cancer: from bench to clinical trials

Y Gu, B Dong, X He, Z Qiu, J Zhang, M Zhang… - Pharmacological …, 2023 - Elsevier
Integrins are main cell adhesion receptors serving as linker attaching cells to extracellular
matrix (ECM) and bidirectional hubs transmitting biochemical and mechanical signals …

Review of integrin‐targeting biomaterials in tissue engineering

P Dhavalikar, A Robinson, Z Lan… - Advanced …, 2020 - Wiley Online Library
The ability to direct cell behavior has been central to the success of numerous therapeutics
to regenerate tissue or facilitate device integration. Biomaterial scientists are challenged to …

SARS-CoV-2 Infects Human ACE2-Negative Endothelial Cells through an αvβ3 Integrin-Mediated Endocytosis Even in the Presence of Vaccine-Elicited Neutralizing …

A Bugatti, F Filippini, M Bardelli, A Zani, P Chiodelli… - Viruses, 2022 - mdpi.com
Integrins represent a gateway of entry for many viruses and the Arg-Gly-Asp (RGD) motif is
the smallest sequence necessary for proteins to bind integrins. All Severe Acute Respiratory …

ITGA5 promotes tumor angiogenesis in cervical cancer

X Xu, L Shen, W Li, X Liu, P Yang, J Cai - Cancer Medicine, 2023 - Wiley Online Library
Purpose Integrins are critical to cancer progression. Integrin alpha 5 (ITGA5) is correlated
with the prognosis of cervical cancer patients. However, whether ITGA5 plays an active role …

[HTML][HTML] Early diagnosis of bladder cancer by photoacoustic imaging of tumor-targeted gold nanorods

E Alchera, M Monieri, M Maturi, I Locatelli, E Locatelli… - Photoacoustics, 2022 - Elsevier
Detection and removal of bladder cancer lesions at an early stage is crucial for preventing
tumor relapse and progression. This study aimed to develop a new technological platform …

Potential of peptide‐engineered exosomes with overexpressed miR‐92b‐3p in anti‐angiogenic therapy of ovarian cancer

J Wang, C Wang, Y Li, M Li, T Zhu… - Clinical and …, 2021 - Wiley Online Library
Abstract Introduction Exosomal microRNA (miRNA) as a mediator of intercellular
communication plays an essential part in tumor‐relevant angiogenesis. Therapy against …

Material matters: exploring the interplay between natural biomaterials and host immune system

AS Tripathi, MEA Zaki, SA Al-Hussain… - Frontiers in …, 2023 - frontiersin.org
Biomaterials are widely used for various medical purposes, for instance, implants, tissue
engineering, medical devices, and drug delivery systems. Natural biomaterials can be …