Lipid and small-molecule display by CD1 and MR1

I Van Rhijn, DI Godfrey, J Rossjohn… - Nature reviews …, 2015 - nature.com
The antigen-presenting molecules CD1 and MHC class I-related protein (MR1) display lipids
and small molecules to T cells. The antigen display platforms in the four CD1 proteins are …

[HTML][HTML] Natural killer T cells and the regulation of asthma

P Matangkasombut, M Pichavant, RH Dekruyff… - Mucosal …, 2009 - Elsevier
A crucial role has been suggested for invariant natural killer T cells (iNKT) in regulating the
development of asthma, a complex and heterogeneous disease characterized by airway …

MAIT cell-MR1 reactivity is highly conserved across multiple divergent species

MD Edmans, TK Connelley, S Morgan… - Journal of Biological …, 2024 - jbc.org
Mucosal-associated invariant T (MAIT) cells are a subset of unconventional T cells that
recognize small molecule metabolites presented by major histocompatibility complex class I …

A Humanized Mouse Model Coupled with Computational Analysis Identifies Potent Glycolipid Agonist of Invariant NKT Cells

NA Saavedra-Avila, NB Pigni, DR Caldwell… - ACS Chemical …, 2024 - ACS Publications
Invariant natural killer T (iNKT) cells play an important role in many innate and adaptive
immune responses, with potential applications in cancer immunotherapy. The glycolipid …

Single-cell gene expression analysis of cryopreserved equine bronchoalveolar cells

SE Sage, P Nicholson, LM Peters, T Leeb… - Frontiers in …, 2022 - frontiersin.org
The transcriptomic profile of a cell population can now be studied at the cellular level using
single-cell mRNA sequencing (scRNA-seq). This novel technique provides the …

Invariant natural killer T cells: innate‐like T cells with potent immunomodulatory activities

L Wu, CL Gabriel, VV Parekh, L Van Kaer - Tissue antigens, 2009 - Wiley Online Library
Invariant natural killer T (iNKT) cells are a subset of T lymphocytes that react with glycolipid
antigens presented by the major histocompatibility complex class I‐related glycoprotein …

Coevolution of T‐cell receptors with MHC and non‐MHC ligands

CD Castro, AM Luoma, EJ Adams - Immunological reviews, 2015 - Wiley Online Library
The structure and amino acid diversity of the T‐cell receptor (TCR), similar in nature to that of
Fab portions of antibodies, would suggest that these proteins have a nearly infinite capacity …

Role of group 1 CD1-restricted T cells in infectious disease

S Siddiqui, L Visvabharathy, CR Wang - Frontiers in immunology, 2015 - frontiersin.org
The evolutionarily conserved CD1 family of antigen-presenting molecules presents lipid
antigens rather than peptide antigens to T cells. CD1 molecules, unlike classical MHC …

The Vγ9Vδ2 T cell antigen receptor and butyrophilin-3 A1: models of interaction, the possibility of co-evolution, and the case of dendritic epidermal T cells

MM Karunakaran, T Herrmann - Frontiers in immunology, 2014 - frontiersin.org
Most circulating human gamma delta T cells are Vγ9Vδ2 T cells. Their hallmark is the
expression of T cell antigen receptors (TCR) whose γ-chains show a Vγ9-JP (Vγ2-Jγ1. 2) …

NKT and MAIT invariant TCRα sequences can be produced efficiently by VJ gene recombination

HY Greenaway, B Ng, DA Price, DC Douek… - Immunobiology, 2013 - Elsevier
Semi-invariant T cell receptors (TCRs) found on natural killer T (NKT) and mucosal-
associated invariant T (MAIT) cells are characterized by the use of invariant variable (V) and …