Panel 2: Eustachian tube, middle ear, and mastoid—anatomy, physiology, pathophysiology, and pathogenesis

JD Swarts, CM Alper, M Luntz… - … —Head and Neck …, 2013 - journals.sagepub.com
Objective This report reviews the literature to identify the advances in our understanding of
the middle ear (ME)–Eustachian tube (ET) system during the past 4 years and, on that basis …

Direct delivery of antisense oligonucleotides to the middle and inner ear improves hearing and balance in Usher mice

JJ Lentz, B Pan, A Ponnath, CM Tran, C Nist-Lund… - Molecular Therapy, 2020 - cell.com
Usher syndrome is a syndromic form of hereditary hearing impairment that includes
sensorineural hearing loss and delayed-onset retinitis pigmentosa (RP). Type 1 Usher …

Audiologic profiles of children with otitis media with effusion

S Al-Salim, RM Tempero, H Johnson… - Ear and …, 2021 - journals.lww.com
Objectives: To describe the impact of effusion volume, viscosity, and purulence on the
audiologic profiles of children with otitis media with effusion. Design: Fifty-one ears from …

Mechanical damage of tympanic membrane in relation to impulse pressure waveform–a study in chinchillas

RZ Gan, D Nakmali, XD Ji, K Leckness, Z Yokell - Hearing research, 2016 - Elsevier
Mechanical damage to middle ear components in blast exposure directly causes hearing
loss, and the rupture of the tympanic membrane (TM) is the most frequent injury of the ear …

Central and peripheral auditory abnormalities in chinchilla animal model of blast-injury

N Shao, S Jiang, D Younger, T Chen, M Brown… - Hearing research, 2021 - Elsevier
Exposure to blast overpressure or high-intensity sound can cause injuries to the auditory
system, which leads to hearing loss or tinnitus. In this study, we examined the involvement of …

Prestin as an otologic biomarker of cisplatin ototoxicity in a guinea pig model

J Naples, R Cox, G Bonaiuto… - … –Head and Neck …, 2018 - journals.sagepub.com
Objective To evaluate (1) whether changes in serum prestin aid in early detection of cisplatin
ototoxicity,(2) the role of diltiazem as an otoprotectant, and (3) whether prestin levels are …

A model of chronic, transmissible Otitis Media in mice

KK Dewan, DL Taylor-Mulneix, LL Campos… - PLoS …, 2019 - journals.plos.org
Infection and inflammation of the middle ears that characterizes acute and chronic o titis m
edia (OM), is a major reason for doctor visits and antibiotic prescription, particularly among …

Hearing damage induced by blast overpressure at mild TBI level in a chinchilla model

KD Smith, T Chen, RZ Gan - Military medicine, 2020 - academic.oup.com
Introduction The peripheral auditory system and various structures within the central auditory
system are vulnerable to blast injuries, and even blast overpressure is at relatively mild …

Mitochondria-targeted antioxidant mitoquinone reduces cisplatin-induced ototoxicity in guinea pigs

AD Tate, PJ Antonelli… - … –Head and Neck …, 2017 - journals.sagepub.com
Objective To determine if mitoquinone (MitoQ) attenuates cisplatin-induced hearing loss in
guinea pigs. Study Design Prospective and controlled animal study. Setting Academic …

Progressive hearing damage after exposure to repeated low-intensity blasts in chinchillas

T Chen, K Smith, S Jiang, T Zhang, RZ Gan - Hearing Research, 2019 - Elsevier
Hearing damage caused by blast waves is a frequent and common injury for Service
members. However, most studies have focused on high-intensity blast exposures that are …