Guidelines for in vivo mouse models of myocardial infarction

ML Lindsey, KR Brunt, JA Kirk… - American Journal …, 2021 - journals.physiology.org
Despite significant improvements in reperfusion strategies, acute coronary syndromes all too
often culminate in a myocardial infarction (MI). The consequent MI can, in turn, lead to …

Large and small animal models of heart failure with reduced ejection fraction

PM Pilz, JE Ward, WT Chang, A Kiss, E Bateh… - Circulation …, 2022 - Am Heart Assoc
Heart failure (HF) describes a heterogenous complex spectrum of pathological conditions
that results in structural and functional remodeling leading to subsequent impairment of …

Immune cells in cardiac homeostasis and disease: emerging insights from novel technologies

S Steffens, M Nahrendorf, R Madonna - European Heart Journal, 2022 - academic.oup.com
The increasing use of single-cell immune profiling and advanced microscopic imaging
technologies has deepened our understanding of the cardiac immune system, confirming …

Preclinical models of myocardial infarction: from mechanism to translation

TP Martin, EA MacDonald… - British Journal of …, 2022 - Wiley Online Library
Approximately 7 million people are affected by acute myocardial infarction (MI) each year,
and despite significant therapeutic and diagnostic advancements, MI remains a leading …

Single-cell transcriptomics reveal distinctive patterns of fibroblast activation in heart failure with preserved ejection fraction

JD Lanzer, LM Wienecke, RO Ramirez Flores… - Basic Research in …, 2024 - Springer
Inflammation, fibrosis and metabolic stress critically promote heart failure with preserved
ejection fraction (HFpEF). Exposure to high-fat diet and nitric oxide synthase inhibitor N [w] …

[HTML][HTML] Large animal models of cardiac ischemia-reperfusion injury: Where are we now?

A Rahman, Y Li, TK Chan, H Zhao, Y Xiang… - Zoological …, 2023 - ncbi.nlm.nih.gov
Large animal models of cardiac ischemia-reperfusion are critical for evaluation of the
efficacy of cardioprotective interventions prior to clinical translation. Nonetheless, current …

Finding the right balance on the challenging path to clinical translation of anti-inflammatory therapies for ischemic heart disease

S Sattler - Nature Cardiovascular Research, 2024 - nature.com
Although anti-inflammatory drugs have shown promising results in preclinical cardiovascular
research, they have yielded little benefit in clinical trials. Before we can expect positive …

Standardisation and future of preclinical echocardiography

CE O'Riordan, P Trochet, M Steiner, D Fuchs - Mammalian Genome, 2023 - Springer
Echocardiography is a non-invasive imaging technique providing real-time information to
assess the structure and function of the heart. Due to advancements in technology, ultra …

Single-cell transcriptomics reveal distinctive patterns of fibroblast activation in murine heart failure with preserved ejection fraction

JD Lanzer, LM Wienecke, RO Ramirez-Flores… - bioRxiv, 2023 - biorxiv.org
Inflammation, fibrosis and metabolic stress critically promote heart failure with preserved
ejection fraction (HFpEF). Exposure to high-fat diet and nitric oxide synthase inhibitor N [w] …

Spatial omics of acute myocardial infarction reveals a novel mode of immune cell infiltration

F Wuennemann, F Sicklinger, K Bestak, J Nimo… - bioRxiv, 2024 - biorxiv.org
Myocardial infarction (MI) continues to be a leading cause of death worldwide. Even though
it is well-established that the complex interplay between different cell types determines the …