Ever since the signal hypothesis was proposed in 1971, the exact nature of signal peptides
has been a focus point of research. The prediction of signal peptides and protein subcellular …

Transmembrane proteins span the lipid bilayer and are divided into two major structural
classes, namely alpha helical and beta barrels. We introduce DeepTMHMM, a deep …

At the heart of all biological processes lies the control of nuclear gene expression, which is
primarily achieved through the action of transcription factors (TFs) that generally contain a …

Disc-like lipid nanoparticles stabilized by saponin biosurfactants display fascinating
properties, including their temperature-driven re-organization. β-Aescin, a saponin from …

Various drug transporters are widely expressed throughout the intestine and play important
roles in absorbing nutrients and drugs, thus providing high quality targets for the design of …

Membrane proteins mediate a wide spectrum of biological processes, such as signal
transduction and cell communication. Due to the arduous and costly nature inherent to the …

Transmembrane proteins are active in amphipathic environments. To stabilize the protein in
such surrounding the exposure of hydrophobic residues on the protein surface is required …

Despite major successes with inhibitory receptor blockade in cancer, the identification of
novel inhibitory receptors as putative drug targets is needed due to lack of durable …

Background Membrane proteins are key gates that control various vital cellular functions.
Membrane proteins are often detected using transmembrane topology prediction tools …

Peripheral membrane proteins (PMPs) bind temporarily to the surface of biological
membranes. They also exist in a soluble form and their tertiary structure is often known. Yet …