Diabetes mellitus (DM) is a typical chronic disease that can be divided into 2 types,
dependent on insulin deficiency or insulin resistance. Incidences of diabetic complications …

Recent data suggests that (pre) diabetes onset is preceded by a period of hyperinsulinemia.
Consumption of the “modern” Western diet, over-nutrition, genetic background, decreased …

In numerous brain structures, insulin signaling modulates the homeostatic processes,
sensitivity to reward pathways, executive function, memory, and cognition. Through human …

Prolonged excess of glucocorticoids (GCs) has adverse systemic effects leading to
significant morbidities and an increase in mortality. Metabolic alterations associated with the …

The concept of insulin resistance has been around since a few decades after the discovery
of insulin itself. To allude to the classic Charles Dicken's novel published 62 years before the …

Neurotrophins including brain-derived neurotrophic factor, BDNF, have critical roles in
neuronal differentiation, cell survival, and synaptic function in the peripheral and central …

Aims To evaluate glycaemic profiles of COVID-19 patients without diabetes receiving
dexamethasone and determine factors associated with hyperglycaemia. Methods All …

Stress and depression increase the risk of Type 2 Diabetes (T2D) development. Evidence
demonstrates that the Glucocorticoid (GC) negative feedback is impaired (GC resistance) in …

Background Stem cell therapies are finally coming of age as a viable alternative to
pancreatic islet transplantation for the treatment of insulin-dependent diabetes. Several …

Chronic stress contributes to the onset of type 2 diabetes (T2D), yet the underlying
etiological mechanisms are not fully understood. Responses to stress are influenced by …