Glioblastoma (GBM) is the most common and malignant astrocytic glioma, accounting for
about 90% of all brain tumors with poor prognosis. Despite recent advances in …

Wnt is a complex signaling pathway involved in the regulation of crucial biological functions
such as development, proliferation, differentiation and migration of cells, mainly stem cells …

Wnt/β-catenin signaling plays a crucial role throughout all stages of brain development and
remains important in the adult brain. Accordingly, many neurological disorders have been …

Background A major barrier to effective treatment of glioblastoma (GBM) is the large
intertumoral heterogeneity at the genetic and cellular level. In early phase clinical trials …

Frizzled7 is arguably the most studied member of the Frizzled family, which are the cognate
Wnt receptors. Frizzled7 is highly conserved through evolution, from Hydra through to …

Simple Summary Wnt signaling is one of the main evolutionarily conserved developmental
pathways needed to instruct embryo formation and maintenance of organ tissues. Decades …

Purpose Constructed from a theoretical framework, the coordinated undermining of survival
paths in glioblastoma (GBM) is a combination of nine drugs approved for non-oncological …

Glioblastoma multiforme is the most frequent primary malignancy of the central nervous
system. Despite remarkable progress towards an understanding of tumor biology, there is no …

Despite decades of research and major efforts, malignant brain tumors remain among the
deadliest of all cancers. Recently, an increasing number of psychiatric drugs has been …

BACKGROUND: Tumor cell invasion is a hallmark of glioblastoma (GBM) and a major
contributing factor for treatment failure, tumor recurrence, and the poor prognosis of GBM …