The causes of preeclampsia remain one of the great medical mysteries of our time. This
syndrome is thought to occur in 2 stages with abnormal placentation leading to a maternal …

Physiological and molecular processes initiated during implantation for pregnancy success
are complex but highly organized. This review primarily highlights adverse ripple effects …

The placenta sits at the interface between the maternal and fetal vascular beds where it
mediates nutrient and waste exchange to enable in utero existence. Placental cells …

The placenta provides critical transport functions between the maternal and fetal circulations
during intrauterine development. Formation of this interface relies on coordinated …

Preeclampsia (PE), a hypertensive disorder, occurs in 3% to 8% of pregnancies in the
United States and affects over 200,000 women and newborns per year. The United States …

Placenta previa, placenta accreta, and vasa previa cause significant maternal and perinatal
morbidity and mortality. With the increasing incidence of both cesarean delivery and …

During human pregnancy, a subset of placental cytotrophoblasts (CTBs) differentiates into
cells that aggressively invade the uterus and its vasculature, anchoring the progeny and …

Implantation is initiated when the embryo attaches to the uterine luminal epithelium during
early pregnancy. Following this event, uterine stromal cells undergo steroid hormone …

Leukemia inhibitory factor (LIF), a downstream target of estrogen, is essential for
implantation in mice. LIF function is thought to be mediated by its binding to LIF receptor …

Maternal decidua plays a critical role in implantation and placentation. Impaired
decidualization causes failed intravascular trophoblast invasion and inadequate …