RecQ DNA helicases are a conserved protein family found in bacteria, fungus, plants, and
animals. These helicases play important roles in multiple cellular functions, including DNA …

Small molecules that deter the functions of DNA damage response machinery are
postulated to be useful for enhancing the DNA damaging effects of chemotherapy or ionizing …

Abstract The Werner syndrome RecQ helicase WRN was identified as a synthetic lethal
target in cancer cells with microsatellite instability (MSI) by several genetic screens …

Microparticles have a demonstrated value for drug delivery systems. The attempts to
develop this technology focus on the generation of featured microparticles for improving the …

Aging, the universal phenomenon, affects human health and is the primary risk factor for
major disease pathologies. Progeroid diseases, which mimic aging at an accelerated rate …

Microparticles with strong adhesion property was presented as efficacious drug delivery
systems. Here, inspired by natural pollen, polymer microparticles with surface textures and …

Werner Syndrome (WS) is an autosomal recessive disorder characterized by the premature
development of aging features. Individuals with WS also have a greater predisposition to …

Impaired DNA repair drives mutagenicity, which increases neoantigen load and
immunogenicity. We investigated the expression of proteins involved in the DNA damage …

Bilirubin and bile acids have deleterious effects on osteoblasts, which may explain the low
bone formation of liver diseases with cholestasis. Although there is some clinical evidence of …

The DNA damage response (DDR) involves the activation of numerous cellular activities that
repair DNA lesions and maintain genomic integrity, and is critical in preventing …