Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity

MS Hansen, K Madsen, M Price, K Søe, Y Omata… - Bone Research, 2024 - nature.com
Enhanced osteoclastogenesis and osteoclast activity contribute to the development of
osteoporosis, which is characterized by increased bone resorption and inadequate bone …

Identification of ferroptosis-associated biomarkers for the potential diagnosis and treatment of postmenopausal osteoporosis

Y Hu, J Han, S Ding, S Liu, H Wang - Frontiers in Endocrinology, 2022 - frontiersin.org
Objective Postmenopausal osteoporosis (PMOP) is one of the most commonly occurring
conditions worldwide and is characterized by estrogen deficiency as well as persistent …

Analysis and validation of hub genes in blood monocytes of postmenopausal osteoporosis patients

YX Deng, WG He, HJ Cai, JH Jiang, YY Yang… - Frontiers in …, 2022 - frontiersin.org
Osteoporosis is a common systemic bone disease caused by the imbalance between
osteogenic activity and osteoclastic activity. Aged women are at higher risk of osteoporosis …

Prognostic analysis and validation of diagnostic marker genes in patients with osteoporosis

X Wang, Z Pei, T Hao, J Ariben, S Li, W He… - Frontiers in …, 2022 - frontiersin.org
Backgrounds As a systemic skeletal dysfunction, osteoporosis (OP) is characterized by low
bone mass and bone microarchitectural damage. The global incidences of OP are high …

Anti‐Postmenopausal osteoporosis effects of Isopsoralen: A bioinformatics‐integrated experimental study

H Li, C Wang, Y Jin, Y Cai, J Yao, Q Meng… - Phytotherapy …, 2023 - Wiley Online Library
Isopsoralen (IPRN), which comes from the fruit of Psoralea corylifolia, has been identified as
a kind of phytoestrogen and has been proven to be effective for the treatment of …

Exploring the various functions of PHD finger protein 20: beyond the unknown

U Juang, S Gwon, W Jung, H Nguyen, Q Huang… - Toxicological …, 2024 - Springer
Over the last decade, the functions of PHD finger protein 20 (PHF20) in several signaling
processes have been studied, including those of protein kinase B (PKB)-mediated …

Identification and experimental validation of key m6A modification regulators as potential biomarkers of osteoporosis

Y Qiao, J Li, D Liu, C Zhang, Y Liu, S Zheng - Frontiers in genetics, 2023 - frontiersin.org
Osteoporosis (OP) is a severe systemic bone metabolic disease that occurs worldwide.
During the coronavirus pandemic, prioritization of urgent services and delay of elective care …

[HTML][HTML] MicroRNA-483-5p inhibits osteogenic differentiation of human bone marrow mesenchymal stem cells by targeting the RPL31-mediated RAS/MEK/ERK …

H Peng, Y Yu, H Gu, B Qi, A Yu - Cellular Signalling, 2022 - Elsevier
Abstract miR-483-5p has been shown to play a key regulatory role in mediating a variety of
biological activities. However, there are only a few studies on how miR-483-5p regulates …

Circulating Monocytes Act as a Common Trigger for the Calcification Paradox of Osteoporosis and Carotid Atherosclerosis via TGFB1-SP1 and TNFSF10-NFKB1 Axis

Z Zeng, R Guo, Z Wang, H Yan, X Lv, Q Zhao… - Frontiers in …, 2022 - frontiersin.org
Background Osteoporosis often occurs with carotid atherosclerosis and causes contradictory
calcification across tissue in the same patient, which is called the “calcification paradox” …

High bone mass disorders: new insights from connecting the clinic and the bench

DJM Bergen, A Maurizi, MM Formosa… - Journal of Bone and …, 2020 - academic.oup.com
Monogenic high bone mass (HBM) disorders are characterized by an increased amount of
bone in general, or at specific sites in the skeleton. Here, we describe 59 HBM disorders …