Pharmacotherapy evolution in Alzheimer's disease: current framework and relevant directions

DC Miculas, PA Negru, SG Bungau, T Behl, SS Hassan… - Cells, 2022 - mdpi.com
Alzheimer's disease (AD), once considered a rare disease, is now the most common form of
dementia in the elderly population. Current drugs (cholinesterase inhibitors and glutamate …

Cannabinoids as medicinals

JH Khalsa, G Bunt, K Blum, SB Maggirwar… - Current addiction …, 2022 - Springer
Purpose of review There have been many debates, discussions, and published writings
about the therapeutic value of cannabis plant and the hundreds of cannabinoids it contains …

The cannabinoids, CBDA and THCA, rescue memory deficits and reduce amyloid-beta and tau pathology in an Alzheimer's disease-like mouse model

J Kim, P Choi, YT Park, T Kim, J Ham… - International journal of …, 2023 - mdpi.com
Most studies related to hemp are focused on Cannabidiol (CBD) and Tetrahydrocannabinol
(THC); however, up to 120 types of phytocannabinoids are present in hemp. Hemp leaves …

The bright side of psychedelics: latest advances and challenges in neuropharmacology

A Mastinu, M Anyanwu, M Carone, G Abate… - International Journal of …, 2023 - mdpi.com
The need to identify effective therapies for the treatment of psychiatric disorders is a
particularly important issue in modern societies. In addition, difficulties in finding new drugs …

[HTML][HTML] Wonder or evil?: multifaceted health hazards and health benefits of Cannabis sativa and its phytochemicals

S Datta, PC Ramamurthy, U Anand, S Singh… - Saudi journal of …, 2021 - Elsevier
Cannabis sativa, widely known as 'Marijuana'poses a dilemma for being a blend of both
good and bad medicinal effects. The historical use of Cannabis for both medicinal and …

Role of Terpenoids Active Ingredients Targeting for Neuroprotective Agents

N Kashyap, R Kumar, V Rana, P Sood… - Journal for Research in …, 2023 - jrasb.com
Neuroinflammation is a characteristic sign of a wide variety of neurodegenerative diseases,
including Alzheimer's and Parkinson's, amongst others. Microglia, which are native immune …

Dual-acting small molecules: subtype-selective cannabinoid receptor 2 agonist/butyrylcholinesterase inhibitor hybrids show neuroprotection in an Alzheimer's disease …

P Spatz, SAM Steinmüller, A Tutov… - Journal of Medicinal …, 2023 - ACS Publications
We present the synthesis and characterization of merged human butyrylcholinesterase (h
BChE) inhibitor/cannabinoid receptor 2 (h CB2R) ligands for the treatment of …

Δ8-THC Protects against Amyloid Beta Toxicity Modulating ER Stress In Vitro: A Transcriptomic Analysis

A Gugliandolo, S Blando, S Salamone… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) represents the most common form of dementia, characterized by
amyloid β (Aβ) plaques and neurofibrillary tangles (NFTs). It is characterized by …

[HTML][HTML] Cannabis sativa and cannabidiol: a therapeutic strategy for the treatment of neurodegenerative diseases?

MB Viana, PEA Aquino, D Estadella… - Medical Cannabis and …, 2022 - karger.com
This work is a literature review, presenting the current state of the use of cannabinoids on
neurodegenerative diseases. The emphasis is on Parkinson's (PD) and Alzheimer's (AD) …

Evaluating Cannabis sativa L.'s neuroprotection potential: From bench to bedside

JS Laws III, SD Smid - Phytomedicine, 2022 - Elsevier
Background Neurodegenerative diseases and dementia pose a global health challenge in
an aging population, exemplified by the increasing incidence and prevalence of its most …