Cyclizations of N-Acyliminium Ions | Chemical Reviews ACS ACS Publications C&EN CAS
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Four-membered monocyclic aza-heterocycles, 1 despite their indisputable importance as
bioactive compounds and pharmaceutical tools, have received by the chemical community …

We report practical methodology for the catalytic, asymmetric synthesis of β-lactams
resulting from the development of a catalyzed reaction of ketenes (or their derived …

Evaluating the aromaticity of a molecular system and the influence of this concept on its
properties is a crucial step in the development of novel aromatic systems. Modern …

The relative (cis, trans) stereoselectivity of the β-lactam formation is one of the critical issues
in the Staudinger reaction. Although many attempts have been made to explain and to …

1. Introduction b-Lactam or azetidin-2-one is an important structural motif of the penicillin,
cephalosporin, carbapenem, and carbecephem classes of antibiotics. 1 Naturally occurring …

Cycloaddition reactions between ketenes, bearing amino‐, oxy‐, or halo‐groups, and imines
are recognized as being amongst the most important and direct routes to β‐lactams. Alkyl …

The report by Staudinger in 1907 of the reactions of diphenylketene (1) with
benzylideneaniline (2), benzaldehyde, and cyclopentadiene forming [2þ2] adducts 3–5 …

We present herein stereoselective synthesis of novel β-lactams using polyaromatic imines
following the Staudinger reaction. Consistent mechanisms for these results have been …

The carbonylation of carbenes through catalytic cycles is highly desirable due to the
importance of ketene-mediated reactions in organic synthesis. In this investigation, a highly …