The transforming growth factor-β (TGF-β) system signals via protein kinase receptors and
SMAD mediators to regulate a large number of biological processes. Alterations of the TGF …

Over the past two decades, the perceived role of transforming growth factor ß (TGF-ß) in
carcinogenesis has undergone more plot twists than an Agatha Christie mystery. The initial …

Aberrant TGFβ signaling is common in human cancers and contributes to tumor metastasis.
Here, we demonstrate that Gr-1+ CD11b+ myeloid cells are recruited into mammary …

TGF-β binding to the cell surface triggers activation of multiple signal transduction pathways
that are connected in intricate ways with each other, and with other response networks …

Transforming growth factor-beta (TGF-β) is a multifunctional regulatory polypeptide that is
the prototypical member of a large family of cytokines that controls many aspects of cellular …

TGF-β signaling regulates tumorigenesis and in human cancer its signaling pathways are
often modified during tumor progression. Prior to initiation and early during progression TGF …

Most human invasive breast cancers (IBCs) appear to develop over long periods of time
from certain pre-existing benign lesions. Of the many types of benign lesions in the human …

The TGF-β signaling network plays a complex role in carcinogenesis because it has the
potential to act as either a tumor suppressor or a pro-oncogenic pathway. Currently, it is not …

Background Clinical decisions about atypical lobular hyperplasia are based on the belief
that later invasive breast-cancer risk is equal in both breasts. We aimed to show laterality …

Transforming growth factor (TGF)-β is a multifunctional cytokine expressed by almost every
tissue and cell type. The signal transduction of TGF-β can stimulate diverse cellular …