Meiosis produces haploid gametes through a succession of chromosomal events, including
pairing, synapsis, and recombination. Mechanisms that orchestrate these events remain …

Oocyte quality control culls eggs with defects in meiosis. In mouse, oocyte death can be
triggered by defects in chromosome synapsis and recombination, which involve repair of …

Dibutyl phthalate (DBP), one of the most widely used plasticizers, is a known environmental
endocrine disruptor that impairs male and female fertility. In this study, oral administration of …

vinylcyclohexene diepoxide (VCD), widely used in industry, is a hazardous compound that
can cause premature ovarian failure, but whether maternal VCD exposure affects the health …

Chromatin spread techniques have been widely used to assess the dynamic localization of
various proteins during gametogenesis, particularly for spermatogenesis. These techniques …

NIMA-related kinase 1 (NEK1) is a serine/threonine and tyrosine kinase that is highly
expressed in mammalian germ cells. Mutations in Nek1 induce anemia, polycystic kidney …

The association between the accumulation of synthetic chemicals with estrogenic activity
and risks to oogenesis has become a growing concern. This study indicates that in utero …

Persistence of unrepaired DNA damage in oocytes is detrimental and may cause genetic
aberrations, miscarriage, and infertility. RPA, an ssDNA-binding complex, is essential for …

Recently, we reported that, in the naked mole-rat (Heterocephalus glaber) ovary, there is
mitotic expansion of the primordial germ cells (PGCs), and the initiation of the meiotic …

In meiotic prophase I, hundreds of double-strand breaks (DSB) are induced to initiate
homologous recombination, resulting in the formation of non-crossovers (NCO) and …