[HTML][HTML] Functionalized liposomes for targeted breast cancer drug delivery
Despite the exceptional progress in breast cancer pathogenesis, prognosis, diagnosis, and
treatment strategies, it remains a prominent cause of female mortality worldwide …
treatment strategies, it remains a prominent cause of female mortality worldwide …
Phospholipase A2 superfamily in cancer
Z Peng, Y Chang, J Fan, W Ji, C Su - Cancer Letters, 2021 - Elsevier
Phospholipase A2 enzymes (PLA 2 s) comprise a superfamily that is generally divided into
six subfamilies known as cytosolic PLA 2 s (cPLA 2 s), calcium-independent PLA 2 s (iPLA 2 …
six subfamilies known as cytosolic PLA 2 s (cPLA 2 s), calcium-independent PLA 2 s (iPLA 2 …
Emodin induces apoptosis and suppresses non-small-cell lung cancer growth via downregulation of sPLA2-IIa
Background Lung cancer has become the principal cause of cancer-related deaths. Emodin
is a Chinese herb-derived compound extracted from the roots of Rheum officinale that …
is a Chinese herb-derived compound extracted from the roots of Rheum officinale that …
Phospholipase Family Enzymes in Lung Cancer: Looking for Novel Therapeutic Approaches
S Salucci, B Aramini, A Bartoletti-Stella, I Versari… - Cancers, 2023 - mdpi.com
Simple Summary This review highlights the role of phospholipase in lung cancer, a topic
which should be better elucidated considering that phospholipase signaling plays a crucial …
which should be better elucidated considering that phospholipase signaling plays a crucial …
Recent progress of nanomedicine in secreted phospholipase A2 as a potential therapeutic target
D Shi, C Feng, J Xie, X Zhang, HL Dai… - Journal of Materials …, 2022 - pubs.rsc.org
Overexpressed secretory phospholipase A2 (sPLA2) is found in many inflammatory
diseases and various types of cancer. sPLA2 can catalyze the hydrolysis of phospholipid sn …
diseases and various types of cancer. sPLA2 can catalyze the hydrolysis of phospholipid sn …
Facial Amphiphile-Modified Lipids Highly Sensitize Liposomes toward Secretory Phospholipase A2
Y Liu, X Yao, C Wen, D Li, J Zhang, B Xi… - Molecular …, 2024 - ACS Publications
Upregulated secretory phospholipase A2 (sPLA2) in tumors has been proposed as a
stimulus to trigger drug release from liposomes for therapeutic effects. However, the current …
stimulus to trigger drug release from liposomes for therapeutic effects. However, the current …
Liposomes Targeting P21 Activated Kinase-1 (PAK-1) and Selective for Secretory Phospholipase A2 (sPLA2) Decrease Cell Viability and Induce Apoptosis in …
W Najahi-Missaoui, ND Quach, PR Somanath… - International Journal of …, 2020 - mdpi.com
P21 activated kinases (or group I PAKs) are serine/threonine kinases whose expression is
altered in prostate and breast cancers. PAK-1 activity is inhibited by the small molecule …
altered in prostate and breast cancers. PAK-1 activity is inhibited by the small molecule …
Stachydrine represses the proliferation and enhances cell cycle arrest and apoptosis of breast cancer cells via PLA2G2A/DCN axis
Z Zhai, T Mu, L Zhao, D Zhu, X Zhong… - Chemical Biology & …, 2024 - Wiley Online Library
Considering the therapeutic efficacy of Stachydrine on breast cancer (BC), this study aims to
decipher the relevant mechanism. The effects of Stachydrine on BC cell viability …
decipher the relevant mechanism. The effects of Stachydrine on BC cell viability …
[PDF][PDF] Secretory Phospholipase A2 Digital Expression Analysis in Colon Adenocarcinoma
E Falidas, E Kitsiouli, D Spyropoulou, E Tsiambas… - in vivo, 2022 - iv.iiarjournals.org
Background/Aim: Phospholipases A2 represent a family of enzymes that regulate the
metabolism of phospholipids by hydrolyzing them into fatty acids. Secretory phospholipase …
metabolism of phospholipids by hydrolyzing them into fatty acids. Secretory phospholipase …