Resistance to therapeutic treatment and metastatic progression jointly determine a fatal
outcome of cancer. Cancer metastasis and therapeutic resistance are traditionally studied as …

Ewing sarcoma, a highly aggressive bone and soft-tissue cancer, is considered a prime
example of the paradigms of a translocation-positive sarcoma: a genetically rather simple …

Bone and bone marrow are among the most frequent metastatic sites of cancer. The
occurrence of bone metastasis is frequently associated with a dismal disease outcome. The …

Hippo pathway is a master regulator of development, cell proliferation, stem cell function,
tissue regeneration, homeostasis, and organ size control. Hippo pathway relays signals from …

Zebrafish xenotransplantation models are increasingly applied for phenotypic drug
screening to identify small compounds for precision oncology. Larval zebrafish xenografts …

Background Uterine fibroids are highly prevalent, collagen‐rich, mechanically stiff, fibrotic
tumors for which new therapeutic options are needed. Increased extracellular matrix (ECM) …

Accumulating evidence shows that despite clonal origins tumors eventually become
complex communities comprised of phenotypically distinct cell subpopulations. This …

Simple Summary YAP-TEAD protein-protein interaction is a crucial feature in the Hippo
pathway for cancer therapeutics. In this study, to investigate novel YAP-TEAD protein-protein …

Osteosarcoma is the most common primary malignancy of bone in children and adolescents.
Others and our previous studies have shown that Yes-associated protein …

Metabolic rewiring offers novel therapeutic opportunities in cancer. Until recently, there was
scant information regarding soft tissue sarcomas, due to their heterogeneous tissue origin …